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eng Role of heredity in patients with prostate cancer
hrv Uloga naslijeđa u bolesnika s rakom prostate
Katušin, Davorin; Križ, Miljenko; Poka, Željko; Sušanj, Jasminka; Janković, Doroteja
Libri Oncologici Vol. 38, No. 1-3, 2010
We distinguish three epidemiological forms of prostate cancer (PCa): 1) sporadic – occurring randomly in the population; 2) familial – unpredictable and weak clustering of PCa in families; and 3) hereditary – strong clustering and early onset of PCa. It was estimated that approximately 10-20% of patients with PCa have a positive family history. Twenty-eight (3.3%) of 827 patients with histopathologically confirmed PCa in our study had a positive family history with one of the first degree relative (father, son or brother) affected by the diseas...
Hrčak ID: 278480


eng Validation of Epstein Biopsy Criteria for Insignificant Prostate Cancer in Contemporary Cohort of Croatian Patients
Tomašković, Igor; Ulamec, Monika; Tomić, Miroslav; Pezelj, Ivan; Grubišić, Igor; Krušlin, Božo
Collegium antropologicum Vol. 39, No. 3, 2015
Only few reports validated contemporary Epstein criteria for insignificant prostate cancer, and only one being from Europe. Patients with insignificant prostate cancer should be offered active surveillance and spared radical treatment. In our study we tested Epstein biopsy criteria for predicting unfavorable final pathology and biochemical relapse in low risk prostate cancer patients, who were eligible for active surveillance but where treated with radical prostatectomy. Between January 2003 and January 2008, 586 patients were subjected to radi...
Hrčak ID: 166284


eng Transrectal Sonography in Prostate Cancer Detection – Our 25 Years Experience of Implementation
Maričić, Antun; Valenčić, Maksim; Sotošek, Stanislav; Oguić, Romano; Ivančić, Aldo; Ahel, Juraj
Collegium antropologicum Vol. 34 supplement 2, No. 2, 2010
Prostate cancer is a leading public health problem of male population in developed countries. Gold standard for prostate cancer diagnosis is true cut biopsy guided by transrectal ultrasound1–5. Aim of this study was to determine sensitivity, specificity, accuracy, positive and negative predictive value of transrectal sonography (TRUS) in prostate cancer detection. The analysis was made for two time periods, before and after routine implementation of prostate specific antigen (PSA) in prostate cancer diagnostics. From 1984 to 1993 TRUS guided pr...
Hrčak ID: 51666


eng Role of Screening in Detection of Clinically Localized Prostate Cancer
Galić, Josip; Karner, Ivan; Ćenan, Ljiljana; Tucak, Antun; Vranješ, Željko; Bilandžija-Peranović, Marijana; Hegeduš, Ivana
Collegium antropologicum Vol. 27 - Supplement 1, No. 1, 2003
The aim of this study was to confirm the role of screening by determining the percentage of clinically localized prostate cancer (stage A and B) in patients with prostate cancer detected on screening and in those presenting to urologic clinic for the symptoms of urination impairment or ostalgia. During the study, 1,000 men aged  50 from the community of ^epin and village of Josipovac near Osijek were examined. The subjects with elevated concentration of total prostate specific antigen and/or digital rectal examination suspect of carcinom...
Hrčak ID: 28121


eng Evolution of the Clinical Presentation and Outcomes after Radical Prostatectomy for Patients with Clinically Localized Prostate Cancer – Changing Trends over a Ten Year Period
Štimac, Goran; Dimanovski, Jordan; Trnski, Davor; Katušić, Josip; Ružić, Boris; Spajić, Borislav; Reljić, Ante; Padovan, Milko; Kraus, Ognjen
Collegium antropologicum Vol. 31, No. 4, 2007
We demonstrate the evolution of the clinical presentation and outcomes for patients with clinically localized prostate cancer (PC) treated with radical retropubic prostatectomy (RRP) at our department, emphasizing epidemiologic significance of changes during the 10-year period.We assessed the annual trends for changes in patients age, preoperative prostate specific antigen (PSA), preoperative versus postoperative stages and Gleason grades, organ confined status and surgical margin status. A total of 488 RRPs were performed from January 1996...
Hrčak ID: 26938


eng Pathophysiology of hormone-resistant prostate cancer
BELEV, BORISLAV; ŠIPIĆ, TOMISLAV
Periodicum biologorum Vol. 116, No. 4, 2014
Androgen-deprivation therapy (ADT) has been for many years the cornerstone of metastatic prostate carcinoma (PC) treatment. It is very well documented that the majority of cancer cells in prostate gland remain androgen responsive what was the basis for androgen suppression in treatment. Nevertheless, after some time or sometimes initially, PCa cells become resistant to castration serum level of testosteron, because of some genetic and epigenetic changes that make them independent from hormone activation. There are two therories – the clonal the...
Hrčak ID: 137761


eng Polymorphisms in Toll-like Receptor Genes – Implications for Prostate Cancer Development
Vidas, Željko
Collegium antropologicum Vol. 34, No. 2, 2010
Toll-like receptors are key players in initiation of innate immune response of the host. In addition to innate immunity they can also induce adaptive immune responses. The concept that inflammation can promote chronic prostatic diseases, such as benign prostatic hyperplasia or prostate carcinoma is supported by several new findings. Epidemiological data have correlated prostatitis with an increased risk of prostate cancer, while PCR-based analyses of bacterial colonization in prostate cancer specimens and normal prostate tissue showed high corr...
Hrčak ID: 56552


eng The Rising Incidence and Mortality of Prostate Cancer in Belgrade Population
Janković, Janko; Šipetić, Sandra
Collegium antropologicum Vol. 35, No. 2, 2011
The purpose of this study was to analyze the epidemiological situation of prostate cancer in Belgrade population. Morbidity data were obtained from the Institute of Public Health of Serbia for the period 1999–2005. Mortality data for the period 1990–2006, were derived from the Statistical Office of Republic of Serbia. Average standardized incidence and mortality rates for the prostate cancer were 33.57 and 11.86 respectively. Standardized incidence rates of prostate cancer steadily increased from 29.34 per 100,000 in 1999 to 36.86 per 100,0...
Hrčak ID: 69134


eng Laparoscopic Radical Prostatectomy - Analysis of Our First 100 Consecutive Cases
Vodopija, Nado; Zupančič, Marko; Koršič, Ljubo; Kramer, Franc; Parać, Ivan
Collegium antropologicum Vol. 28, No. 1, 2004
The aim of this study was retrospective study of our first 100 consecutive cases of prostatic cancer, operated by laparoscopic approach and comparison with 100 cases of open retropubic radical prostatectomy (RRP) at our department, focusing on operative data and morbidity. From June 1999 to August 2003 we have performed first consecutive 100 laparoscopic radical prostatectomies (LRP), all according to Montsouris technique. In this study we have compared the results with 100 patients who underwent from May 1997 to August 2003 open RRP. Mean oper...
Hrčak ID: 4924


eng Epidemiology of Prostate Cancer in the Mediterranean Population of Croatia – A Thirty-Three Years Retrospective Study
Španjol, Josip; Maričić, Anton; Cicvarić, Tedi; Valenčić, Maksim; Oguić, Romano; Tadin, Tomislav; Fučkar, Dora; Bobinac, Mirna
Collegium antropologicum Vol. 31, No. 1, 2007
Prostate cancer is a major public health problem of the male population in all the developed countries1. This non-skin cancer is the foremost one facing man today. Prostate cancer has become the second leading cause of cancer death2. In this study we investigated changes in the prostate carcinoma incidence and manifestation during a thirty-three years period. The study included 1,226 cases of prostate cancer diagnosed from 1972 to 2005 in the Primorsko-Goranska County, Croatia. The age-adjusted incidence of prostate cancer increased from 1....
Hrčak ID: 27324