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Hyperserotonemia in Autism: The Potential Role of 5HT-related Gene Variants

Dubravka Hranilović
Ruđer Novak
Marina Babić
Mislav Novokmet
Zorana Bujas-Petković
Branimir Jernej

Puni tekst: engleski, pdf (102 KB) str. 75-80 preuzimanja: 763* citiraj
APA 6th Edition
Hranilović, D., Novak, R., Babić, M., Novokmet, M., Bujas-Petković, Z. i Jernej, B. (2008). Hyperserotonemia in Autism: The Potential Role of 5HT-related Gene Variants. Collegium antropologicum, 32 - Supplement 1 (1), 75-80. Preuzeto s https://hrcak.srce.hr/24557
MLA 8th Edition
Hranilović, Dubravka, et al. "Hyperserotonemia in Autism: The Potential Role of 5HT-related Gene Variants." Collegium antropologicum, vol. 32 - Supplement 1, br. 1, 2008, str. 75-80. https://hrcak.srce.hr/24557. Citirano 28.02.2020.
Chicago 17th Edition
Hranilović, Dubravka, Ruđer Novak, Marina Babić, Mislav Novokmet, Zorana Bujas-Petković i Branimir Jernej. "Hyperserotonemia in Autism: The Potential Role of 5HT-related Gene Variants." Collegium antropologicum 32 - Supplement 1, br. 1 (2008): 75-80. https://hrcak.srce.hr/24557
Harvard
Hranilović, D., et al. (2008). 'Hyperserotonemia in Autism: The Potential Role of 5HT-related Gene Variants', Collegium antropologicum, 32 - Supplement 1(1), str. 75-80. Preuzeto s: https://hrcak.srce.hr/24557 (Datum pristupa: 28.02.2020.)
Vancouver
Hranilović D, Novak R, Babić M, Novokmet M, Bujas-Petković Z, Jernej B. Hyperserotonemia in Autism: The Potential Role of 5HT-related Gene Variants. Collegium antropologicum [Internet]. 2008 [pristupljeno 28.02.2020.];32 - Supplement 1(1):75-80. Dostupno na: https://hrcak.srce.hr/24557
IEEE
D. Hranilović, R. Novak, M. Babić, M. Novokmet, Z. Bujas-Petković i B. Jernej, "Hyperserotonemia in Autism: The Potential Role of 5HT-related Gene Variants", Collegium antropologicum, vol.32 - Supplement 1, br. 1, str. 75-80, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/24557. [Citirano: 28.02.2020.]

Sažetak
Increased platelet serotonin level (PSL) has been consistently found in a portion of autistic patients. Suggested mechanisms
for hyperserotonemia in autism have been increased synthesis of serotonin (5HT) by tryptophan hydroxylase
(TPH), increased uptake into platelets through 5HT transporter (5HTt), diminished release from platelets through 5HT2A
receptor (5HT2Ar) and decreased metabolism by monoamine oxydase (MAOA). The allelic influence of genes, encoding
the mentioned 5HT elements, on PSL was investigated in 63 autistic subjects. Our study shows that 5HTt-LPR and
–1438AG 5HT2Ar genotypes did not significantly affect PSL. However, significantly higher PSLs were observed in subjects
with »cc« genotype of a218c TPH and subjects with »4« genotype of uVNTR MAOA. In addition, when TPH-cc and
MAOA-4 were combined as »high 5HT« genotypes, a correlative increase in PSL was observed with the increase in the
number of »high 5HT« genotypes. These results suggest a possible synergistic effect of genes regulating 5HT synthesis/
degradation in dysregulation of the peripheral 5HT homeostasis of autistic patients.

Ključne riječi
autism; hyperserotonemia; serotonin transporter; tryptophan hydroxylase; monoamine oxydase A; 5HT2A receptor

Hrčak ID: 24557

URI
https://hrcak.srce.hr/24557

Posjeta: 986 *