Izvorni znanstveni članak
Analysis of the C609T Polymorphism of NQO1 Gene in South Croatian Patients with Hematological Malignancies
Bernarda Lozić
Dragan Primorac
Robert Glavinić
Radenka Kuzmanić Šamija
Tatijana Zemunik
Sažetak
In this study we analyzed the effect of polymorphic variation of NAD(P)H: quinone oxidoreductase1 (NQO1) gene that
encode enzyme which detoxifies harmful quinines and protect hematopoietic stem cells against oxidative stress. C609T
polymorphism of NQO1 gene leads to loss of enzyme activity, which may be a risk factor in the etiology of specific types of
hematopoietic malignancies.We analyzed C609T polymorphism in NQO1 gene in the group of 82 patients (56 adult and
26 children) with different type of hematopoietic malignancies and 99 healthy participants (61 adult and 38 children)
using PCR and the RFLP method. We confirmed that the polymorphism C609T in NQO1 gene was more frequent in the
adult patients’ group with myeloid disorders, (p=0.0267) compared with adult controls.We could not confirm the association
C609T polymorphism with recurrent chromosome translocations (clonal karyotype changes) neither in the adult
nor in pediatric group of patients.
Ključne riječi
hematological malignancies; polymorphism; NQO1; clonal chromosomal abnormalities
Hrčak ID:
68949
URI
Datum izdavanja:
24.6.2011.
Posjeta: 932 *