hrcak mascot   Srce   HID

Izvorni znanstveni članak
https://doi.org/10.5562/cca1753

Flow-injection Spectrophotometric Determination of N-acetyl-L-cysteine Based on Coupled Redox-complexation Reaction

Lea Kukoč - Modun   ORCID icon orcid.org/0000-0003-1798-6796 ; Department of Analytical Chemistry, Faculty of Chemistry and Technology, University of Split, Teslina 10/V, 21000 Split, Croatia
Ivana Plazibat   ORCID icon orcid.org/0000-0002-7082-3710 ; Department of Analytical Chemistry, Faculty of Chemistry and Technology, University of Split, Teslina 10/V, 21000 Split, Croatia
Njegomir Radić ; Department of Analytical Chemistry, Faculty of Chemistry and Technology, University of Split, Teslina 10/V, 21000 Split, Croatia

Puni tekst: engleski, pdf (2 MB) str. 81-86 preuzimanja: 761* citiraj
APA 6th Edition
Kukoč - Modun, L., Plazibat, I. i Radić, Nj. (2011). Flow-injection Spectrophotometric Determination of N-acetyl-L-cysteine Based on Coupled Redox-complexation Reaction. Croatica Chemica Acta, 84 (1), 81-86. https://doi.org/10.5562/cca1753
MLA 8th Edition
Kukoč - Modun, Lea, et al. "Flow-injection Spectrophotometric Determination of N-acetyl-L-cysteine Based on Coupled Redox-complexation Reaction." Croatica Chemica Acta, vol. 84, br. 1, 2011, str. 81-86. https://doi.org/10.5562/cca1753. Citirano 08.08.2020.
Chicago 17th Edition
Kukoč - Modun, Lea, Ivana Plazibat i Njegomir Radić. "Flow-injection Spectrophotometric Determination of N-acetyl-L-cysteine Based on Coupled Redox-complexation Reaction." Croatica Chemica Acta 84, br. 1 (2011): 81-86. https://doi.org/10.5562/cca1753
Harvard
Kukoč - Modun, L., Plazibat, I., i Radić, Nj. (2011). 'Flow-injection Spectrophotometric Determination of N-acetyl-L-cysteine Based on Coupled Redox-complexation Reaction', Croatica Chemica Acta, 84(1), str. 81-86. https://doi.org/10.5562/cca1753
Vancouver
Kukoč - Modun L, Plazibat I, Radić Nj. Flow-injection Spectrophotometric Determination of N-acetyl-L-cysteine Based on Coupled Redox-complexation Reaction. Croatica Chemica Acta [Internet]. 2011 [pristupljeno 08.08.2020.];84(1):81-86. https://doi.org/10.5562/cca1753
IEEE
L. Kukoč - Modun, I. Plazibat i Nj. Radić, "Flow-injection Spectrophotometric Determination of N-acetyl-L-cysteine Based on Coupled Redox-complexation Reaction", Croatica Chemica Acta, vol.84, br. 1, str. 81-86, 2011. [Online]. https://doi.org/10.5562/cca1753

Sažetak
A flow-injection spectrophotometric method is developed for determination of N-acetyl-L-cysteine (NAC) in pharmaceutical formulations. The method is based on coupled redox-complexation reaction, the first step of which is the reduction of FeIII by NAC; the second one includes the complexation of FeII, resulting from the preceding redox reaction, with 2,4,6-tripyridyl-s-triazine (TPTZ). The stable Fe(TPTZ)22+ complex exhibits an absorption maximum at λ = 593 nm. Under experimental conditions, optimized by univariate method, a linear calibration curve is established in NAC concentration range from 6.0×10−6 mol L–1 to 2.0×10–4 mol L–1 with NAC detection limit of 2.0×10–6 mol L–1. The analytical fre-quency was 60 h–1. Usual excipients used as additives in pharmaceuticals do not interfere with the analysis of NAC. The proposed method is simple, rapid, sensitive, accurate and precise (repeatability RSD 0.29 %, n = 10), and can be applied for determination of NAC in pharmaceutical formulations up to nano- mole quantity. (doi: 10.5562/cca1753)

Ključne riječi
N-acetyl-L-cysteine; flow-injection spectrophotometry; pharmaceuticals

Hrčak ID: 69702

URI
https://hrcak.srce.hr/69702

Posjeta: 1.099 *