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Croatica Chemica Acta, Vol. 84 No. 2, 2011.

Pregledni rad

https://doi.org/10.5562/cca1817

Neurochemical and Behavioural Changes in Rat Models of Depression

Ivan Skelin ; Cone Neurosurgical Research Laboratory, Montreal Neurological Institute, Department for Neurology and Neurosurgery, McGill University, H3A2B4 Montreal QC, Canada
Tomislav Kovačević ; Cone Neurosurgical Research Laboratory, Montreal Neurological Institute, Department for Neurology and Neurosurgery, McGill University, H3A2B4 Montreal QC, Canada; Faculty of Medicine, J. J. Strossmayer University of Osijek, 31000 Osijek, Croatia
Mirko Diksic orcid id orcid.org/0000-0001-8070-6051 ; Cone Neurosurgical Research Laboratory, Montreal Neurological Institute, Department for Neurology and Neurosurgery, McGill University, H3A2B4 Montreal QC, Canada; Faculty of Medicine, J. J. Strossmayer University of Osijek, 31000 Osijek, Croatia

Puni tekst: engleski pdf 1.216 Kb

str. 287-299

preuzimanja: 1.825

citiraj

Sažetak

Depression is one of the most prevalent psychiatric disorders with significant lifetime prevalence.
The study of human depression is hindered by the relatively significant heterogeneity of this disorder.
As a result of these heterogeneities, studies using a sound and representative animal model of depression
are extremely valuable and, in general, provide important information regarding the neurochemical/
biological changes occurring during depression and the subsequent treatment of its symptoms. In this
review we concentrate on two solid rat models of depression: olfactory bulbectomized (OBX) rats and
Flinders Sensitive Line (FSL) of rats. These two models were selected because they possess all three characteristics
of a good animal model; face, predictive and constructive validities. We also emphasize the
brain serotonergic system and we discuss the open field and forced swim test to assess behaviour. (doi:
10.5562/cca1817)

Ključne riječi

depression; olfactory bulbectomized rat model of depression; Flinders sensitive line rat; Flinders Resistant line rat; animal model of depression

Hrčak ID:

71992

URI

https://hrcak.srce.hr/71992

Datum izdavanja:

3.10.2011.

Posjeta: 2.524 *