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Pregledni rad
https://doi.org/10.5562/cca1809

Kinetic Approach to Biomineralization: Interactions of Synthetic Polypeptides with Calcium Carbonate Polymorphs

Branka Njegić-Džakula ; Laboratory for Precipitation Processes, Ruđer Bošković Institute, P. O. Box 180, HR–10002 Zagreb, Croatia
Ljerka Brečević ; Laboratory for Precipitation Processes, Ruđer Bošković Institute, P. O. Box 180, HR–10002 Zagreb, Croatia
Giuseppe Falini ; Dipartimento di Chimica "G. Ciamician", Università di Bologna, via Selmi 2, 40126 Bologna, Italy
Damir Kralj ; Laboratory for Precipitation Processes, Ruđer Bošković Institute, P. O. Box 180, HR–10002 Zagreb, Croatia

Puni tekst: engleski, pdf (12 MB) str. 301-314 preuzimanja: 1.081* citiraj
APA 6th Edition
Njegić-Džakula, B., Brečević, Lj., Falini, G. i Kralj, D. (2011). Kinetic Approach to Biomineralization: Interactions of Synthetic Polypeptides with Calcium Carbonate Polymorphs. Croatica Chemica Acta, 84 (2), 301-314. https://doi.org/10.5562/cca1809
MLA 8th Edition
Njegić-Džakula, Branka, et al. "Kinetic Approach to Biomineralization: Interactions of Synthetic Polypeptides with Calcium Carbonate Polymorphs." Croatica Chemica Acta, vol. 84, br. 2, 2011, str. 301-314. https://doi.org/10.5562/cca1809. Citirano 12.11.2019.
Chicago 17th Edition
Njegić-Džakula, Branka, Ljerka Brečević, Giuseppe Falini i Damir Kralj. "Kinetic Approach to Biomineralization: Interactions of Synthetic Polypeptides with Calcium Carbonate Polymorphs." Croatica Chemica Acta 84, br. 2 (2011): 301-314. https://doi.org/10.5562/cca1809
Harvard
Njegić-Džakula, B., et al. (2011). 'Kinetic Approach to Biomineralization: Interactions of Synthetic Polypeptides with Calcium Carbonate Polymorphs', Croatica Chemica Acta, 84(2), str. 301-314. https://doi.org/10.5562/cca1809
Vancouver
Njegić-Džakula B, Brečević Lj, Falini G, Kralj D. Kinetic Approach to Biomineralization: Interactions of Synthetic Polypeptides with Calcium Carbonate Polymorphs. Croatica Chemica Acta [Internet]. 2011 [pristupljeno 12.11.2019.];84(2):301-314. https://doi.org/10.5562/cca1809
IEEE
B. Njegić-Džakula, Lj. Brečević, G. Falini i D. Kralj, "Kinetic Approach to Biomineralization: Interactions of Synthetic Polypeptides with Calcium Carbonate Polymorphs", Croatica Chemica Acta, vol.84, br. 2, str. 301-314, 2011. [Online]. https://doi.org/10.5562/cca1809

Sažetak
Biomineralization processes are the subject of numerous investigations. This article gives a review
of the study on interactions between the charged polypeptides and the mineral surfaces involved in
biomineralization, with an additional kinetic approach. The influence of polypeptides on two types of precipitation
processes is discussed: the spontaneous precipitation from supersaturated solution and the
growth kinetics of calcite seed crystals. In the first case the phenomenon of the formation and stabilization
of metastable phases was found while in the second case the influence of the applied polypeptides on the
kinetics and mechanisms of calcite crystal growth was investigated. Calcium carbonate polymorphs, calcite
and vaterite, were used as biomineral substrates and acidic polypeptides, poly-L-aspartic (pAsp) acid
and poly-L-glutamic (pGlu) acid, as simplified models of naturally occurring soluble acidic proteins. A
basic polypeptide, poly-L-lysine (pLys), was also used in experiments in order to find out whether conformity
between the crystal surface and the adsorbed polypeptide, or just the electrostatic interactions,
have a decisive role in these processes. The addition of a particular polypeptide into the precipitation system
caused a significant inhibition of nucleation and growth of vaterite, the extent of inhibition being in
the order InhpAsp > InhpGlu >> InhpLys. In addition to the inhibition of precipitation, the change of the polymorphic
composition and the crystal morphology of the precipitate were also achieved. The explanation of
such acidic polypeptide behaviour is a consequence of kinetic constraints through the diverse efficiency of
inhibition of both calcite nucleation and vaterite growth caused by adsorption of acidic polypeptides. The
acidic polypeptides also caused the inhibition of calcite crystal growth, the effect being pAsp > pGlu, and
changed the observed mechanism of growth controlled by the integration of ions into the spiral steps, as
found for the model systems, to the surface nucleation rate-determining mechanism. Nonselective, weak
and electrostatic adsorption of pLys at the crystal surface was probably responsible for increasing the calcite
crystal growth rate when pLys was present at low concentrations and for inhibiting it at pLys higher
concentrations. The strongest interactions between the crystal surfaces and the polypeptides, observed for
the calcite/pAsp system, can account for coordinative interactions between the side chain carboxylic
groups of the predominantly planar arrangement of the pAsp structure (β-pleated sheet) and Ca2+ ions
from the crystal surface. (doi: 10.5562/cca1809)

Ključne riječi
calcium carbonate; calcite; vaterite; amorphous calcium carbonate; poly-L-aspartic acid; poly-L-glutamic acid; poly-L-lysine

Hrčak ID: 71993

URI
https://hrcak.srce.hr/71993

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