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Biochemical Screening of Fetal Aneuploidies and Neural Tube Defects by »Double-Test« in Croatia: A 10 Years’ Experience

Dubravka Tišlarić-Medenjak
Vesna Košec
Ivana Tonković-Đurišević
Ivana Zec
Senka Sabolović-Rudman
Krunoslav Kuna
Radoslav Herman
Tomislav Ivičević-Bakulić
Hrvojka Soljačić-Vraneš
Neven Tučkar
Dubravka Mužinić
Dražan Butorac
Ivan Bolanča
Andro Košec
Feodora Stipoljev

Puni tekst: engleski, pdf (87 KB) str. 957-962 preuzimanja: 504* citiraj
APA 6th Edition
Tišlarić-Medenjak, D., Košec, V., Tonković-Đurišević, I., Zec, I., Sabolović-Rudman, S., Kuna, K., ... Stipoljev, F. (2011). Biochemical Screening of Fetal Aneuploidies and Neural Tube Defects by »Double-Test« in Croatia: A 10 Years’ Experience. Collegium antropologicum, 35 (3), 957-962. Preuzeto s https://hrcak.srce.hr/72207
MLA 8th Edition
Tišlarić-Medenjak, Dubravka, et al. "Biochemical Screening of Fetal Aneuploidies and Neural Tube Defects by »Double-Test« in Croatia: A 10 Years’ Experience." Collegium antropologicum, vol. 35, br. 3, 2011, str. 957-962. https://hrcak.srce.hr/72207. Citirano 15.07.2019.
Chicago 17th Edition
Tišlarić-Medenjak, Dubravka, Vesna Košec, Ivana Tonković-Đurišević, Ivana Zec, Senka Sabolović-Rudman, Krunoslav Kuna, Radoslav Herman, et al. "Biochemical Screening of Fetal Aneuploidies and Neural Tube Defects by »Double-Test« in Croatia: A 10 Years’ Experience." Collegium antropologicum 35, br. 3 (2011): 957-962. https://hrcak.srce.hr/72207
Harvard
Tišlarić-Medenjak, D., et al. (2011). 'Biochemical Screening of Fetal Aneuploidies and Neural Tube Defects by »Double-Test« in Croatia: A 10 Years’ Experience', Collegium antropologicum, 35(3), str. 957-962. Preuzeto s: https://hrcak.srce.hr/72207 (Datum pristupa: 15.07.2019.)
Vancouver
Tišlarić-Medenjak D, Košec V, Tonković-Đurišević I, Zec I, Sabolović-Rudman S, Kuna K i sur. Biochemical Screening of Fetal Aneuploidies and Neural Tube Defects by »Double-Test« in Croatia: A 10 Years’ Experience. Collegium antropologicum [Internet]. 2011 [pristupljeno 15.07.2019.];35(3):957-962. Dostupno na: https://hrcak.srce.hr/72207
IEEE
D. Tišlarić-Medenjak, et al., "Biochemical Screening of Fetal Aneuploidies and Neural Tube Defects by »Double-Test« in Croatia: A 10 Years’ Experience", Collegium antropologicum, vol.35, br. 3, str. 957-962, 2011. [Online]. Dostupno na: https://hrcak.srce.hr/72207. [Citirano: 15.07.2019.]

Sažetak
The aim of the study is to investigate the efficiency of the second-trimester biochemical screening, with maternal serum
alpha-fetoprotein (MS-AFP) and free b-subunit of human chorionic gonadotropin (free b-hCG), during the ten-year
period. The study included 11,292 of pregnant women between the 15th and 18th gestational week, who underwent screening
from November 1996 to December 2006. The risk for trisomy 21 and trisomy 18 were calculated by computer software,
based on a model which generated the final risk for fetal aneuploidies from the pregnant woman’s a priori age risk
and the likelihood ratio of the distribution of the biochemical markers, according to the second-trimester gestation. With
the cut-off value of the final risk 1:250, the detection rate for trisomy 21 was 75% (21/28). In women less than or equal to
35, the detection was 57.1% (8/14) and 92.9% (13/14) in those over 35 years, respectively. The detection rate of trisomy 18
was 50% (2/4). The results confirmed that the implementation of double-test, as non-invasive screening for fetal aneuploidies,
should be accepted as a complementary method of antenatal care.

Ključne riječi
Down syndrome screening; second-trimester; alpha-fetoprotein; hCG free b-subunit; fetal aneuplodies; neural tube defects

Hrčak ID: 72207

URI
https://hrcak.srce.hr/72207

Posjeta: 913 *