Veterinarski arhiv, Vol. 81 No. 5, 2011.
Izvorni znanstveni članak
The effects of selenium and tocopherol supplementation on the efficacy of diminazene aceturate in reversing T. brucei-induced anemia in rats
Kingsley I. Eghianruwa
orcid.org/0000-0002-5440-0486
; Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Nigeria
Silvanus M. Anika
; Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria
Sažetak
This study investigated the separate influence of selenium or tocopherol supplementation on the efficacy of diminazene aceturate in reversing the anemia caused by Trypanosoma brucei infection in rats. Changes in PCV, hemoglobin and RBC on day 7 post infection and days 7, 14 and 21 post treatment with diminazene aceturate at 7 mg/kg BW were evaluated. Hemoglobin concentration attained the highest level in the diminazene/ tocopherol group by day 7 PT compared to the diminazene/selenium and diminazene groups. The mean PCV in the diminazene/tocopherol and diminazene/selenium groups were significantly higher than the PCV recorded in the diminazene group on day 7 PT. Hematological parameters (PCV, Hb and RBC) maintained upward trends in the diminazene and diminazene/selenium groups with the values of PCV, Hb and RBC becoming higher in the diminazene/selenium groups, but values declined in the diminazene/tocopherol groups by day 14 and 21 PT. The higher levels of hematological parameters in the antioxidant supplemented groups within the first week showed that antioxidant supplementation led to the more rapid return of these parameters to normal. The results indicate that a trypanocide/antioxidant combination may have significant therapeutic application in trypanosomosis.
Ključne riječi
diminazene; tocopherol; selenium; Trypanosoma brucei; rat; antioxidant; supplementation
Hrčak ID:
72964
URI
Datum izdavanja:
20.10.2011.
Posjeta: 1.168 *