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Croatica Chemica Acta, Vol. 84 No. 3, 2011.

Izvorni znanstveni članak
https://doi.org/10.5562/cca1763

Separation of 1,4-benzodiazepine Derivates by Micellar Electrokinetic Capillary Chromatography Using Cyclodextrines as Buffer Modifiers

Gabriel Hancu ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy Târgu Mureş, Gh. Marinescu 38, 540000 Târgu Mureş, Romania
Árpád Gyéresi ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy Târgu Mureş, Gh. Marinescu 38, 540000 Târgu Mureş, Romania

Puni tekst: engleski, pdf (4 MB) str. 349-353 preuzimanja: 744* citiraj
APA 6th Edition
Hancu, G. i Gyéresi, Á. (2011). Separation of 1,4-benzodiazepine Derivates by Micellar Electrokinetic Capillary Chromatography Using Cyclodextrines as Buffer Modifiers. Croatica Chemica Acta, 84 (3), 349-353. https://doi.org/10.5562/cca1763
MLA 8th Edition
Hancu, Gabriel i Árpád Gyéresi. "Separation of 1,4-benzodiazepine Derivates by Micellar Electrokinetic Capillary Chromatography Using Cyclodextrines as Buffer Modifiers." Croatica Chemica Acta, vol. 84, br. 3, 2011, str. 349-353. https://doi.org/10.5562/cca1763. Citirano 07.03.2021.
Chicago 17th Edition
Hancu, Gabriel i Árpád Gyéresi. "Separation of 1,4-benzodiazepine Derivates by Micellar Electrokinetic Capillary Chromatography Using Cyclodextrines as Buffer Modifiers." Croatica Chemica Acta 84, br. 3 (2011): 349-353. https://doi.org/10.5562/cca1763
Harvard
Hancu, G., i Gyéresi, Á. (2011). 'Separation of 1,4-benzodiazepine Derivates by Micellar Electrokinetic Capillary Chromatography Using Cyclodextrines as Buffer Modifiers', Croatica Chemica Acta, 84(3), str. 349-353. https://doi.org/10.5562/cca1763
Vancouver
Hancu G, Gyéresi Á. Separation of 1,4-benzodiazepine Derivates by Micellar Electrokinetic Capillary Chromatography Using Cyclodextrines as Buffer Modifiers. Croatica Chemica Acta [Internet]. 2011 [pristupljeno 07.03.2021.];84(3):349-353. https://doi.org/10.5562/cca1763
IEEE
G. Hancu i Á. Gyéresi, "Separation of 1,4-benzodiazepine Derivates by Micellar Electrokinetic Capillary Chromatography Using Cyclodextrines as Buffer Modifiers", Croatica Chemica Acta, vol.84, br. 3, str. 349-353, 2011. [Online]. https://doi.org/10.5562/cca1763

Sažetak
The applicability of micellar electrokinetic capillary chromatography (MEKC) for the separation
of benzodiazepine (BZD) derivates with different structural characteristics has been studied. Efforts were
first focused on the optimization of the analytical conditions, on the effects of buffer concentration, surfactant
concentration and buffer pH on the separation. To manipulate selectivity of the separation β-
cyclodextrin (CD) was added to the buffer solution, and urea was used to improve the solubility of the CD
in water. The CD-modified MEKC separation of the eight BZDs was achieved within 15 minutes using 25
mmol dm−3 natrium tetraborate-50 mmol dm−3 sodium dodecyl sulphate-15 mmol dm−3 β-CD-2 mol dm−3
urea (pH 9.3) as the running buffer. The proposed separation method was evaluated on the basis of precision,
linearity and limit of detection. (doi: 10.5562/cca1763)

Ključne riječi
benzodiazepines; separation; capillary electrophoresis; micelles; cyclodextrines

Hrčak ID: 74771

URI
https://hrcak.srce.hr/74771

Posjeta: 1.000 *