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https://doi.org/10.5562/cca1738

Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE

Květa Kalíková   ORCID icon orcid.org/0000-0003-4988-8322 ; Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University in Prague, 128 43 Prague 2, Albertov 2030, Czech Republic
Martina Riesová ; Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University in Prague, 128 43 Prague 2, Albertov 2030, Czech Republic
Richard Chudoba ; Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University in Prague, 128 43 Prague 2, Albertov 2030, Czech Republic
Martin G. Schmid ; Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, Karl-Franzens-University Graz, Universitätsplatz 1, A-8010 Graz, Austria
Eva Tesařová ; Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University in Prague, 128 43 Prague 2, Albertov 2030, Czech Republic

Puni tekst: engleski, pdf (3 MB) str. 367-373 preuzimanja: 1.882* citiraj
APA 6th Edition
Kalíková, K., Riesová, M., Chudoba, R., Schmid, M.G. i Tesařová, E. (2011). Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE. Croatica Chemica Acta, 84 (3), 367-373. https://doi.org/10.5562/cca1738
MLA 8th Edition
Kalíková, Květa, et al. "Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE." Croatica Chemica Acta, vol. 84, br. 3, 2011, str. 367-373. https://doi.org/10.5562/cca1738. Citirano 25.02.2021.
Chicago 17th Edition
Kalíková, Květa, Martina Riesová, Richard Chudoba, Martin G. Schmid i Eva Tesařová. "Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE." Croatica Chemica Acta 84, br. 3 (2011): 367-373. https://doi.org/10.5562/cca1738
Harvard
Kalíková, K., et al. (2011). 'Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE', Croatica Chemica Acta, 84(3), str. 367-373. https://doi.org/10.5562/cca1738
Vancouver
Kalíková K, Riesová M, Chudoba R, Schmid MG, Tesařová E. Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE. Croatica Chemica Acta [Internet]. 2011 [pristupljeno 25.02.2021.];84(3):367-373. https://doi.org/10.5562/cca1738
IEEE
K. Kalíková, M. Riesová, R. Chudoba, M.G. Schmid i E. Tesařová, "Separation and Quantification of 1,4-benzodiazepines: HPLC versus CZE", Croatica Chemica Acta, vol.84, br. 3, str. 367-373, 2011. [Online]. https://doi.org/10.5562/cca1738

Sažetak
The goal of the present study was to separate a set of benzodiazepines, namely bromazepam,
oxazepam, nitrazepam, chlordiazepoxide, flunitrazepam, lormetazepam and diazepam by analytical scale
HPLC and CZE. The both methods for separation of these seven compounds from the 1,4-benzodiazepine
group were optimized and compared. LODs and LOQs were determined under the optimized conditions in
the both methods. The corresponding LOD and LOQ values are approximately three orders of magnitude
lower in HPLC than in CZE. As expected, elution order was found to be different for the both techniques.
As a result of a critical collation of all the parameters considered, RP-HPLC was found to be more suitable
for determination of the set of benzodiazepines. A real sample analysis was performed under optimized
conditions to demonstrate applicability of the proposed analytical methods. (doi: 10.5562/cca1738)

Ključne riječi
RP-HPLC; CZE; benzodiazepines; pharmaceuticals

Hrčak ID: 74775

URI
https://hrcak.srce.hr/74775

Posjeta: 2.315 *