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https://doi.org/10.5562/cca1787

Comparative Study of Captopril Derivatization Reaction by LC-UV, LC-MS and CE-UV Methods

Gabriella Donáth-Nagy ; University of Medicine and Pharmacy of Târgu-Mureş, Faculty of Pharmacy, Department of Physical Chemistry, 38 Gh. Marinescu Street, RO-540139 Târgu-Mures, Romania
Szende Vancea ; University of Medicine and Pharmacy of Târgu-Mureş, Faculty of Pharmacy, Department of Physical Chemistry, 38 Gh. Marinescu Street, RO-540139 Târgu-Mures, Romania
Silvia Imre ; University of Medicine and Pharmacy of Târgu-Mureş, Faculty of Pharmacy, Department of Drugs Analysis, 38 Gh. Marinescu Street, RO-540139 Târgu-Mures, Romania

Puni tekst: engleski, pdf (3 MB) str. 423-427 preuzimanja: 1.485* citiraj
APA 6th Edition
Donáth-Nagy, G., Vancea, S. i Imre, S. (2011). Comparative Study of Captopril Derivatization Reaction by LC-UV, LC-MS and CE-UV Methods. Croatica Chemica Acta, 84 (3), 423-427. https://doi.org/10.5562/cca1787
MLA 8th Edition
Donáth-Nagy, Gabriella, et al. "Comparative Study of Captopril Derivatization Reaction by LC-UV, LC-MS and CE-UV Methods." Croatica Chemica Acta, vol. 84, br. 3, 2011, str. 423-427. https://doi.org/10.5562/cca1787. Citirano 07.03.2021.
Chicago 17th Edition
Donáth-Nagy, Gabriella, Szende Vancea i Silvia Imre. "Comparative Study of Captopril Derivatization Reaction by LC-UV, LC-MS and CE-UV Methods." Croatica Chemica Acta 84, br. 3 (2011): 423-427. https://doi.org/10.5562/cca1787
Harvard
Donáth-Nagy, G., Vancea, S., i Imre, S. (2011). 'Comparative Study of Captopril Derivatization Reaction by LC-UV, LC-MS and CE-UV Methods', Croatica Chemica Acta, 84(3), str. 423-427. https://doi.org/10.5562/cca1787
Vancouver
Donáth-Nagy G, Vancea S, Imre S. Comparative Study of Captopril Derivatization Reaction by LC-UV, LC-MS and CE-UV Methods. Croatica Chemica Acta [Internet]. 2011 [pristupljeno 07.03.2021.];84(3):423-427. https://doi.org/10.5562/cca1787
IEEE
G. Donáth-Nagy, S. Vancea i S. Imre, "Comparative Study of Captopril Derivatization Reaction by LC-UV, LC-MS and CE-UV Methods", Croatica Chemica Acta, vol.84, br. 3, str. 423-427, 2011. [Online]. https://doi.org/10.5562/cca1787

Sažetak
The LC-UV, LC-MS and CE-UV study of chemical reaction between captopril and p-bromophenacyl
bromide as derivatizing reagent is reported. During transformation of captopril, its thiol group
is involved and the reaction is irreversible. Neutral or alkaline environments favor derivatization. The
yield of reaction increases linear with the concentration of the reagent, while changes in temperature do
not influence it significantly. Kinetic studies show that derivatization of captopril flows quickly, reaching
a plateau after 30 minutes. Based on the study of these effects some important parameters such as deri- vatizing
agent concentration, reaction time, temperature and pH were confined. The results were used
for development of captopril determination methods both in pharmaceutical formulations and biological
samples. (doi: 10.5562/cca1787)

Ključne riječi
captopril; derivatization; LC-UV; LC-MS; CE-UV

Hrčak ID: 74808

URI
https://hrcak.srce.hr/74808

Posjeta: 1.764 *