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Acta Pharmaceutica, Vol.62 No.1 Ožujak 2012.

Kratko priopćenje
https://doi.org/10.2478/v10007-012-0003-4

Formulation and evaluation of delayed-onset extended-release tablets of metoprolol tartrate using hydrophilic-swellable polymers

SUBHASH CHAND DADARWAL ; Delhi Institute of Pharmaceutical Sciences and Research (Formerly College of Pharmacy) University of Delhi Pushp Vihar, Sec-III, New Delhi-110017, India
SARIKA MADAN ; Delhi Institute of Pharmaceutical Sciences and Research (Formerly College of Pharmacy) University of Delhi Pushp Vihar, Sec-III, New Delhi-110017, India
SHYAM SUNDER Agrawal ; Delhi Institute of Pharmaceutical Sciences and Research (Formerly College of Pharmacy) University of Delhi Pushp Vihar, Sec-III, New Delhi-110017, India

Puni tekst: engleski, pdf (126 KB) str. 105-114 preuzimanja: 964* citiraj
APA 6th Edition
DADARWAL, S.C., MADAN, S. i Agrawal, S.S. (2012). Formulation and evaluation of delayed-onset extended-release tablets of metoprolol tartrate using hydrophilic-swellable polymers. Acta Pharmaceutica, 62 (1), 105-114. https://doi.org/10.2478/v10007-012-0003-4
MLA 8th Edition
DADARWAL, SUBHASH CHAND, et al. "Formulation and evaluation of delayed-onset extended-release tablets of metoprolol tartrate using hydrophilic-swellable polymers." Acta Pharmaceutica, vol. 62, br. 1, 2012, str. 105-114. https://doi.org/10.2478/v10007-012-0003-4. Citirano 11.12.2018.
Chicago 17th Edition
DADARWAL, SUBHASH CHAND, SARIKA MADAN i SHYAM SUNDER Agrawal. "Formulation and evaluation of delayed-onset extended-release tablets of metoprolol tartrate using hydrophilic-swellable polymers." Acta Pharmaceutica 62, br. 1 (2012): 105-114. https://doi.org/10.2478/v10007-012-0003-4
Harvard
DADARWAL, S.C., MADAN, S., i Agrawal, S.S. (2012). 'Formulation and evaluation of delayed-onset extended-release tablets of metoprolol tartrate using hydrophilic-swellable polymers', Acta Pharmaceutica, 62(1), str. 105-114. doi: https://doi.org/10.2478/v10007-012-0003-4
Vancouver
DADARWAL SC, MADAN S, Agrawal SS. Formulation and evaluation of delayed-onset extended-release tablets of metoprolol tartrate using hydrophilic-swellable polymers. Acta Pharm. [Internet]. 2012 [pristupljeno 11.12.2018.];62(1):105-114. doi: https://doi.org/10.2478/v10007-012-0003-4
IEEE
S.C. DADARWAL, S. MADAN i S.S. Agrawal, "Formulation and evaluation of delayed-onset extended-release tablets of metoprolol tartrate using hydrophilic-swellable polymers", Acta Pharmaceutica, vol.62, br. 1, str. 105-114, 2012. [Online]. doi: https://doi.org/10.2478/v10007-012-0003-4

Sažetak
In view of the circadian rhythm of cardiovascular diseases, a delayed-onset extended-release (DOER) formulation of metoprolol tartrate (MT) was prepared. This was achieved through dissolution-guided optimization of the proportion of Methocel K4M and Methocel K15M. Core erosion ratio was greater than 50 %, thereby showing steady release of the drug after the lag time until complete dissolution. Optimized formulation produced a lag phase of 6 h followed by complete release of 98.7 ± 2.1 % in 24 h. Water uptake study revealed that Methocel K15M has lower water uptake (30 ± 1 %) than methocel K4M (40 ± 2 %) after 24 h. Axial swelling of polymers was higher than swelling in the radial direction. Drug-polymer interaction study precludes any interaction between drug and polymer. Such a drug delivery system may provide a viable alternative for effective management of hypertension and other related disorders. This work also proposes an approach to attain DOER for a hydrophilic drug by using a hydrophilic swellable polymer in press coat.

Ključne riječi
metoprolol tartrate; delayed-onset extended-release (DOER); core erosion ratio

Hrčak ID: 76597

URI
https://hrcak.srce.hr/76597

[hrvatski]

Posjeta: 1.260 *