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Acta Pharmaceutica, Vol.62 No.1 Ožujak 2012.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-012-0006-1

Optimization of self-assembling properties of fatty acids grafted to methoxy poly(ethylene glycol) as nanocarriers for etoposide

JALEH VARSHOSAZ ; Department of Pharmaceutics, Faculty of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
FARSHID HASANZADEH ; Department of Medicinal Chemistry, Faculty of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
MOJTABA ESLAMDOOST ; Department of Pharmaceutics, Faculty of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Puni tekst: engleski, pdf (174 KB) str. 31-44 preuzimanja: 426* citiraj
APA 6th Edition
VARSHOSAZ, J., HASANZADEH, F. i ESLAMDOOST, M. (2012). Optimization of self-assembling properties of fatty acids grafted to methoxy poly(ethylene glycol) as nanocarriers for etoposide. Acta Pharmaceutica, 62 (1), 31-44. https://doi.org/10.2478/v10007-012-0006-1
MLA 8th Edition
VARSHOSAZ, JALEH, et al. "Optimization of self-assembling properties of fatty acids grafted to methoxy poly(ethylene glycol) as nanocarriers for etoposide." Acta Pharmaceutica, vol. 62, br. 1, 2012, str. 31-44. https://doi.org/10.2478/v10007-012-0006-1. Citirano 25.09.2018.
Chicago 17th Edition
VARSHOSAZ, JALEH, FARSHID HASANZADEH i MOJTABA ESLAMDOOST. "Optimization of self-assembling properties of fatty acids grafted to methoxy poly(ethylene glycol) as nanocarriers for etoposide." Acta Pharmaceutica 62, br. 1 (2012): 31-44. https://doi.org/10.2478/v10007-012-0006-1
Harvard
VARSHOSAZ, J., HASANZADEH, F., i ESLAMDOOST, M. (2012). 'Optimization of self-assembling properties of fatty acids grafted to methoxy poly(ethylene glycol) as nanocarriers for etoposide', Acta Pharmaceutica, 62(1), str. 31-44. doi: https://doi.org/10.2478/v10007-012-0006-1
Vancouver
VARSHOSAZ J, HASANZADEH F, ESLAMDOOST M. Optimization of self-assembling properties of fatty acids grafted to methoxy poly(ethylene glycol) as nanocarriers for etoposide. Acta Pharm. [Internet]. 31.03.2012. [pristupljeno 25.09.2018.];62(1):31-44. doi: https://doi.org/10.2478/v10007-012-0006-1
IEEE
J. VARSHOSAZ, F. HASANZADEH i M. ESLAMDOOST, "Optimization of self-assembling properties of fatty acids grafted to methoxy poly(ethylene glycol) as nanocarriers for etoposide", Acta Pharmaceutica, vol.62, br. 1, str. 31-44, ožujak 2012. [Online]. doi: https://doi.org/10.2478/v10007-012-0006-1

Sažetak
The objective of this work was to study the effect of fatty acid chain length grafted to methoxy poly(ethylene glycol) (mPEG) on self assembling properties of micelles for etoposide delivery. Three amphiphilic copolymers were synthesized using mPEG, myristic acid, stearic acid and behenic acid through an esteric linkage. The particle size and zeta potential of the micelles were determined by the dynamic light scattering method. Etoposide was loaded into micelles by film casting using various drug/polymer ratios. Drug release was studied by the dialysis method. The structure of copolymers was confirmed by 1H NMR and FTIR. Critical micellar concentration (CMC) measurements showed that the longer hydrophobic chains formed more thermodynamically stable micelles. Among the prepared copolymers, etoposide showed the highest solubility in the mPEG-behenic copolymer. Drug loading efficiency depended on the hydrophobic chain length and drug/polymer ratio. The highest drug loading efficiency was found in mPEG-myristic micelles with 1:20 drug/polymer ratio. Micelles released 80 % of loaded drug within about 5 h.

Ključne riječi
methoxy poly(ethylene glycol); fatty acid; micelles; etoposide

Hrčak ID: 76600

URI
https://hrcak.srce.hr/76600

[hrvatski]

Posjeta: 625 *