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Acta Pharmaceutica, Vol.62 No.1 Ožujak 2012.

Pregledni rad
https://doi.org/10.2478/v10007-012-0010-5

Spherical crystallization of drugs

BORUT KOVAČIČ ; Krka d. d., 8501 Novo mesto, Slovenia; University of Ljubljana, Faculty of Pharmacy, 1000 Ljubljana, Slovenia
FRANC VREČER ; Krka d. d., 8501 Novo mesto, Slovenia; University of Ljubljana, Faculty of Pharmacy, 1000 Ljubljana, Slovenia
ODON PLANINŠEK ; University of Ljubljana, Faculty of Pharmacy, Aškerčeva 7, 1000 Ljubljana, Slovenia

Puni tekst: engleski, pdf (201 KB) str. 1-14 preuzimanja: 911* citiraj
APA 6th Edition
KOVAČIČ, B., VREČER, F. i PLANINŠEK, O. (2012). Spherical crystallization of drugs. Acta Pharmaceutica, 62 (1), 1-14. https://doi.org/10.2478/v10007-012-0010-5
MLA 8th Edition
KOVAČIČ, BORUT, et al. "Spherical crystallization of drugs." Acta Pharmaceutica, vol. 62, br. 1, 2012, str. 1-14. https://doi.org/10.2478/v10007-012-0010-5. Citirano 11.12.2018.
Chicago 17th Edition
KOVAČIČ, BORUT, FRANC VREČER i ODON PLANINŠEK. "Spherical crystallization of drugs." Acta Pharmaceutica 62, br. 1 (2012): 1-14. https://doi.org/10.2478/v10007-012-0010-5
Harvard
KOVAČIČ, B., VREČER, F., i PLANINŠEK, O. (2012). 'Spherical crystallization of drugs', Acta Pharmaceutica, 62(1), str. 1-14. doi: https://doi.org/10.2478/v10007-012-0010-5
Vancouver
KOVAČIČ B, VREČER F, PLANINŠEK O. Spherical crystallization of drugs. Acta Pharm. [Internet]. 2012 [pristupljeno 11.12.2018.];62(1):1-14. doi: https://doi.org/10.2478/v10007-012-0010-5
IEEE
B. KOVAČIČ, F. VREČER i O. PLANINŠEK, "Spherical crystallization of drugs", Acta Pharmaceutica, vol.62, br. 1, str. 1-14, 2012. [Online]. doi: https://doi.org/10.2478/v10007-012-0010-5

Sažetak
Spherical crystallization of drugs is the process of obtaining larger particles by agglomeration during crystallization. The most common techniques used to obtain such particles are spherical agglomeration and quasi-emulsion solvent diffusion. Ammonia diffusion systems and crystallo-co-agglomeration are extensions of these techniques. By controlling process parameters during crystallization, such as temperature, stirring rate, type and amount of solvents, or excipient selection, it is possible to control the formation of agglomerates and obtain spherical particles of the desired size, porosity, or hardness. Researchers have reported that the particles produced have improved micromeritic, physical, and mechanical properties, which make them suitable for direct compression. In some cases, when additional excipients are incorporated during spherical crystallization, biopharmaceutical parameters including the bioavailability of drugs can also be tailored.

Ključne riječi
spherical crystallization; agglomeration; solvent diffusion; improved particle properties

Hrčak ID: 76606

URI
https://hrcak.srce.hr/76606

[slovenski]

Posjeta: 1.189 *