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Review article

Uric acid as one of the important factors in multifactorial disorders – facts and controversies

Daria Pasalic   ORCID icon orcid.org/0000-0002-5741-6168 ; Department of Chemistry, Biochemistry and Clinical Chemistry, University of Zagreb, School of Medicine, Zagreb, Croatia
Natalija Marinkovic ; Quintiles Zagreb Ltd., Zagreb, Croatia
Lana Feher-Turkovic ; Department of Chemistry, Biochemistry and Clinical Chemistry, University of Applied Health Studies, Zagreb, Croatia

Fulltext: english, pdf (240 KB) pages 63-75 downloads: 1.655* cite
APA 6th Edition
Pasalic, D., Marinkovic, N. & Feher-Turkovic, L. (2012). Uric acid as one of the important factors in multifactorial disorders – facts and controversies. Biochemia Medica, 22 (1), 63-75. Retrieved from https://hrcak.srce.hr/77389
MLA 8th Edition
Pasalic, Daria, et al. "Uric acid as one of the important factors in multifactorial disorders – facts and controversies." Biochemia Medica, vol. 22, no. 1, 2012, pp. 63-75. https://hrcak.srce.hr/77389. Accessed 23 Oct. 2020.
Chicago 17th Edition
Pasalic, Daria, Natalija Marinkovic and Lana Feher-Turkovic. "Uric acid as one of the important factors in multifactorial disorders – facts and controversies." Biochemia Medica 22, no. 1 (2012): 63-75. https://hrcak.srce.hr/77389
Harvard
Pasalic, D., Marinkovic, N., and Feher-Turkovic, L. (2012). 'Uric acid as one of the important factors in multifactorial disorders – facts and controversies', Biochemia Medica, 22(1), pp. 63-75. Available at: https://hrcak.srce.hr/77389 (Accessed 23 October 2020)
Vancouver
Pasalic D, Marinkovic N, Feher-Turkovic L. Uric acid as one of the important factors in multifactorial disorders – facts and controversies. Biochemia Medica [Internet]. 2012 [cited 2020 October 23];22(1):63-75. Available from: https://hrcak.srce.hr/77389
IEEE
D. Pasalic, N. Marinkovic and L. Feher-Turkovic, "Uric acid as one of the important factors in multifactorial disorders – facts and controversies", Biochemia Medica, vol.22, no. 1, pp. 63-75, 2012. [Online]. Available: https://hrcak.srce.hr/77389. [Accessed: 23 October 2020]

Abstracts
With considering serum concentration of the uric acid in humans we are observing hyperuricemia and possible gout development. Many epidemiological studies have shown the relationship between the uric acid and different disorders such are obesity, metabolic syndrome, hypertension and coronary artery disease. Clinicians and investigators recognized serum uric acid concentration as very impor-tant diagnostic and prognostic factor of many multifactorial disorders. This review presented few clini-cal conditions which are not directly related to uric acid, but the concentrations of uric acid might have a great impact in observing, monitoring, prognosis and therapy of such disorders. Uric acid is recogni-zed as a marker of oxidative stress. Production of the uric acid includes enzyme xanthine oxidase which is involved in producing of radical-oxigen species (ROS). As by-products ROS have a signifi-cant role in the increased vascular oxidative stress and might be involved in atherogenesis. Uric acid may inhibit endothelial function by inhibition of nitric oxide-function under conditions of oxidative stress. Down regulation of nitric oxide and induction of endothelial dysfunction might also be involved in pathogenesis of hypertension. The most important and well evidenced is possible predictive role of uric acid in predicting short-term outcome (mortality) in acute myocardial infarction (AMI) patients and stroke. Nephrolithiasis of uric acid origin is significantly more common among patients with the meta-bolic syndrome and obesity. On contrary to this, uric acid also acts is an ‘‘antioxidant’’, a free radical scavenger and a chelator of transitional metal ions which are converted to poorly reactive forms.

Keywords
atherosclerosis; hypertension; hyperuricemia; metabolic syndrome; uric acid

Hrčak ID: 77389

URI
https://hrcak.srce.hr/77389

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