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Acta clinica Croatica, Vol.50 No.1 Ožujak 2011.

Izvorni znanstveni članak

Splenic Irradiation in Haematological Malignancies and Other Haematological Disorders – Single Institution Experience

Željko Soldić   ORCID icon orcid.org/0000-0001-8152-0494 ; University Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Jure Murgić ; University Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Marijana Jazvić ; University Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Jasna Radić ; University Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Ante Bolanča ; University Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Vladimir Stančić ; Department of Hematology, University Department of Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Zvonko Kusić ; University Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia

Puni tekst: engleski, pdf (101 KB) str. 29-34 preuzimanja: 1.855* citiraj
APA 6th Edition
Soldić, Ž., Murgić, J., Jazvić, M., Radić, J., Bolanča, A., Stančić, V. i Kusić, Z. (2011). Splenic Irradiation in Haematological Malignancies and Other Haematological Disorders – Single Institution Experience. Acta clinica Croatica, 50 (1), 29-34. Preuzeto s https://hrcak.srce.hr/77413
MLA 8th Edition
Soldić, Željko, et al. "Splenic Irradiation in Haematological Malignancies and Other Haematological Disorders – Single Institution Experience." Acta clinica Croatica, vol. 50, br. 1, 2011, str. 29-34. https://hrcak.srce.hr/77413. Citirano 21.08.2018.
Chicago 17th Edition
Soldić, Željko, Jure Murgić, Marijana Jazvić, Jasna Radić, Ante Bolanča, Vladimir Stančić i Zvonko Kusić. "Splenic Irradiation in Haematological Malignancies and Other Haematological Disorders – Single Institution Experience." Acta clinica Croatica 50, br. 1 (2011): 29-34. https://hrcak.srce.hr/77413
Harvard
Soldić, Ž., et al. (2011). 'Splenic Irradiation in Haematological Malignancies and Other Haematological Disorders – Single Institution Experience', Acta clinica Croatica, 50(1), str. 29-34. Preuzeto s: https://hrcak.srce.hr/77413 (Datum pristupa: 21.08.2018.)
Vancouver
Soldić Ž, Murgić J, Jazvić M, Radić J, Bolanča A, Stančić V i sur. Splenic Irradiation in Haematological Malignancies and Other Haematological Disorders – Single Institution Experience. Acta clinica Croatica [Internet]. 31.03.2011. [pristupljeno 21.08.2018.];50(1):29-34. Dostupno na: https://hrcak.srce.hr/77413
IEEE
Ž. Soldić, et al., "Splenic Irradiation in Haematological Malignancies and Other Haematological Disorders – Single Institution Experience", Acta clinica Croatica, vol.50, br. 1, str. 29-34, Kolovoz 2018. [Online]. Dostupno na: https://hrcak.srce.hr/77413. [Citirano: 21.08.2018.]

Sažetak
Splenic irradiation has long been known as a palliative treatment modality in patients with various malignant hematologic diseases aiming to ameliorate clinical symptoms of splenomegaly as well as clinical sequels of hypersplenism. It provides considerable effect with low toxicity although exact radiotherapy dose and fractionation schedule are not known. During the 1996-2010 period, eleven patients were treated at our institution with splenic irradiation. They received 16 courses of fractionated radiotherapy. There were six patients with non-Hodgkin’s lymphoma, four with chronic lymphocytic leukemia, and one patient with myelofibrosis. The median of the dose received was 7 Gy, while the median of dose received per fraction was 1 Gy. Both parallel opposed anterior-posterior fields and tangential fields were used. Due to the clinical target volume shrinkage, the treatment field was reduced in 44% of courses. Of the courses initiated for symptom control, 71% resulted in effective palliation, whereas of the courses started to treat hematologic sequels of hypersplenism 50% produced desirable effects. The most common side effects included thrombocytopenia and anemia. Splenic irradiation provides effective and low-toxic palliation of symptoms but it is much less successful in treating hematologic disorders caused by hypersplenism.

Ključne riječi
Splenic neoplasms – radiotherapy; Palliative care; Lymphoma, non-Hodgkin; Leukemia; Myelofibrosis

Hrčak ID: 77413

URI
https://hrcak.srce.hr/77413

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