Veterinarski arhiv, Vol. 82 No. 2, 2012.
Izvorni znanstveni članak
Attenuation of interleukin- 1β secretion in mice by post-inflammatory treatment with azithromycin and clarithromycin.
Vanesa Ivetić Tkalčević
; GSK Research Centre Zagreb Ltd., Zagreb, Croatia
Vesna Eraković Haber
; GSK Research Centre Zagreb Ltd., Zagreb, Croatia
Sažetak
The literature indicates that, in addition to anti-bacterial effects, certain macrolide antibiotics, such as azithromycin and clarithromycin, also exert anti-inflammatory and immunomodulatory activity, by accumulating in inflammatory cells and inhibiting the secretion of pro-inflammatory cytokines. Previous reports have shown that pre-treatment with these macrolides attenuates induced immediate skin inflammatory reactions in mice. However, the anti inflammatory activity of the post-inflammatory induction of macrolide antibiotics in this experimental model has not been investigated. The aim of this study was to explore whether the anti-inflammatory activity of azithromycin and clarithromycin, applied transdermally, 30 min after a phorbol 12-myristate 13- acetate (PMA)-induced immediate skin inflammation in mice, could attenuate a Th1 inflammatory reaction. The capacity of azithromycin and clarithromycin (500 μg/ear) to exert anti-inflammatory effects, similar to those of dexamethasone (50 μg/ear), was confirmed by the inhibition by all three agents of ear swelling and interleukin- 1β concentration in the ear tissue of PMA-treated mice, supporting this clinically relevant treatment mode.
Ključne riječi
anti-inflammatory activity; IL-1β; macrolide antibiotic; mouse; skin inflammatio
Hrčak ID:
78273
URI
Datum izdavanja:
8.3.2012.
Posjeta: 1.246 *