hrcak mascot   Srce   HID

Izvorni znanstveni članak
https://doi.org/10.2478/10004-1254-63-2012-2190

Effects of Myosmine on Antioxidative Defence in Rat Liver

Rumyana Simeonova ; Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology,Faculty of Pharmacy, Medical University, Sofia, Bulgaria
Vessela Vitcheva ; Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology,Faculty of Pharmacy, Medical University, Sofia, Bulgaria
Galina Gorneva ; Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, Bulgaria
Mitka Mitcheva ; Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology,Faculty of Pharmacy, Medical University, Sofia, Bulgaria

Puni tekst: engleski, pdf (195 KB) str. 7-13 preuzimanja: 505* citiraj
APA 6th Edition
Simeonova, R., Vitcheva, V., Gorneva, G. i Mitcheva, M. (2012). Effects of Myosmine on Antioxidative Defence in Rat Liver. Arhiv za higijenu rada i toksikologiju, 63 (1), 7-13. https://doi.org/10.2478/10004-1254-63-2012-2190
MLA 8th Edition
Simeonova, Rumyana, et al. "Effects of Myosmine on Antioxidative Defence in Rat Liver." Arhiv za higijenu rada i toksikologiju, vol. 63, br. 1, 2012, str. 7-13. https://doi.org/10.2478/10004-1254-63-2012-2190. Citirano 20.09.2020.
Chicago 17th Edition
Simeonova, Rumyana, Vessela Vitcheva, Galina Gorneva i Mitka Mitcheva. "Effects of Myosmine on Antioxidative Defence in Rat Liver." Arhiv za higijenu rada i toksikologiju 63, br. 1 (2012): 7-13. https://doi.org/10.2478/10004-1254-63-2012-2190
Harvard
Simeonova, R., et al. (2012). 'Effects of Myosmine on Antioxidative Defence in Rat Liver', Arhiv za higijenu rada i toksikologiju, 63(1), str. 7-13. https://doi.org/10.2478/10004-1254-63-2012-2190
Vancouver
Simeonova R, Vitcheva V, Gorneva G, Mitcheva M. Effects of Myosmine on Antioxidative Defence in Rat Liver. Arh Hig Rada Toksikol. [Internet]. 2012 [pristupljeno 20.09.2020.];63(1):7-13. https://doi.org/10.2478/10004-1254-63-2012-2190
IEEE
R. Simeonova, V. Vitcheva, G. Gorneva i M. Mitcheva, "Effects of Myosmine on Antioxidative Defence in Rat Liver", Arhiv za higijenu rada i toksikologiju, vol.63, br. 1, str. 7-13, 2012. [Online]. https://doi.org/10.2478/10004-1254-63-2012-2190

Sažetak
Myosmine [3-(1-pyrrolin-2-yl) pyridine] is an alkaloid structurally similar to nicotine, which is known to induce oxidative stress. In this study we investigated the effects of myosmine on enzymatic and nonenzymatic antioxidative defence in rat liver. Wistar rats received a single i.p. injection of 19 mg kg-1 of myosmine and an oral dose of 190 mg kg-1 by gavage. Nicotine was used as a positive control. Through either route of administration, myosmine altered the hepatic function by decreasing the levels of reduced glutathione, superoxide dismutase, and glutathione peroxidase activities on one hand and by increasing malondialdehyde, catalase, and glutathione reductase activity on the other. Compared to control, both routes caused significant lipid peroxidation in the liver and altered hepatic enzymatic and non-enzymatic antioxidative defences. The pro-oxidant effects of myosmine were comparable with those of nicotine.

Ključne riječi
lipid peroxidation; oxidative stress; rodents; tobacco alkaloid

Hrčak ID: 78631

URI
https://hrcak.srce.hr/78631

[hrvatski]

Posjeta: 841 *