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https://doi.org/10.2478/10004-1254-63-2012-2114

Effects of Taurine on Permethrin-Induced Cytogenetic and Oxidative Damage in Cultured Human Lymphocytes

Hasan Turkez ; Erzurum Technical University, Faculty of Science, Department of Molecular Biology and Genetics, Erzurum, Turkey
Elanur Aydin ; Atatürk University, Faculty of Science, Department of Biology, Erzurum, Turkey

Puni tekst: engleski, pdf (136 KB) str. 27-33 preuzimanja: 497* citiraj
APA 6th Edition
Turkez, H. i Aydin, E. (2012). Effects of Taurine on Permethrin-Induced Cytogenetic and Oxidative Damage in Cultured Human Lymphocytes. Arhiv za higijenu rada i toksikologiju, 63 (1), 27-33. https://doi.org/10.2478/10004-1254-63-2012-2114
MLA 8th Edition
Turkez, Hasan i Elanur Aydin. "Effects of Taurine on Permethrin-Induced Cytogenetic and Oxidative Damage in Cultured Human Lymphocytes." Arhiv za higijenu rada i toksikologiju, vol. 63, br. 1, 2012, str. 27-33. https://doi.org/10.2478/10004-1254-63-2012-2114. Citirano 25.09.2020.
Chicago 17th Edition
Turkez, Hasan i Elanur Aydin. "Effects of Taurine on Permethrin-Induced Cytogenetic and Oxidative Damage in Cultured Human Lymphocytes." Arhiv za higijenu rada i toksikologiju 63, br. 1 (2012): 27-33. https://doi.org/10.2478/10004-1254-63-2012-2114
Harvard
Turkez, H., i Aydin, E. (2012). 'Effects of Taurine on Permethrin-Induced Cytogenetic and Oxidative Damage in Cultured Human Lymphocytes', Arhiv za higijenu rada i toksikologiju, 63(1), str. 27-33. https://doi.org/10.2478/10004-1254-63-2012-2114
Vancouver
Turkez H, Aydin E. Effects of Taurine on Permethrin-Induced Cytogenetic and Oxidative Damage in Cultured Human Lymphocytes. Arh Hig Rada Toksikol. [Internet]. 2012 [pristupljeno 25.09.2020.];63(1):27-33. https://doi.org/10.2478/10004-1254-63-2012-2114
IEEE
H. Turkez i E. Aydin, "Effects of Taurine on Permethrin-Induced Cytogenetic and Oxidative Damage in Cultured Human Lymphocytes", Arhiv za higijenu rada i toksikologiju, vol.63, br. 1, str. 27-33, 2012. [Online]. https://doi.org/10.2478/10004-1254-63-2012-2114

Sažetak
Permethrin (PM) is a common pyrethroid pesticide used to control pests in agriculture, forestry, horticulture, health care, homes, and textile industry. It is confi rmed as a strong mutagen in animals and humans. Taurine (TA) is an amino acid found in mammalian tissues that protects the cell against DNA damage. In this study, we investigated whether supplementation of human lymphocyte cultures with TA (in the concentrations of 25 μg mL-1, 50 μg mL-1 and 100 μg mL-1) provided any protection against PM toxicity applied in the concentration of 200 μg mL-1. Genotoxicity was assessed using the micronucleus (MN) and sister chromatid exchanges (SCE) tests. In addition, we measured the total antioxidant capacity (TAC) and total oxidative stress (TOS) levels in the plasma to determine oxidative effects. PM increased SCE and MN levels and altered TAC and TOS levels. TA alone did not affect SCE and MN levels compared to controls, regardless of the concentration applied. In addition, it increased TAC levels without changing TOS levels. Moreover, it signifi cantly buffered the negative cytogenetic and oxidative effects induced by PM in a clear dose-dependent manner. In conclusion, this study is the first to evidence the beneficial effects of TA against PM-induced DNA and oxidative damages in vitro.

Ključne riječi
antioxidant; micronucleus; pesticide; sister chromatid exchanges

Hrčak ID: 78636

URI
https://hrcak.srce.hr/78636

[hrvatski]

Posjeta: 899 *