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The Role of IgG Avidity in Diagnosis of Cytomegalovirus Infection in Newborns and Infants

Tatjana Vilibić-Čavlek
Sunčanica Ljubin-Sternak
Gordana Vojnović
Mario Sviben
Gordana Mlinarić-Galinović

Puni tekst: engleski, pdf (59 KB) str. 297-300 preuzimanja: 243* citiraj
APA 6th Edition
Vilibić-Čavlek, T., Ljubin-Sternak, S., Vojnović, G., Sviben, M. i Mlinarić-Galinović, G. (2012). The Role of IgG Avidity in Diagnosis of Cytomegalovirus Infection in Newborns and Infants. Collegium antropologicum, 36 (1), 297-300. Preuzeto s https://hrcak.srce.hr/78828
MLA 8th Edition
Vilibić-Čavlek, Tatjana, et al. "The Role of IgG Avidity in Diagnosis of Cytomegalovirus Infection in Newborns and Infants." Collegium antropologicum, vol. 36, br. 1, 2012, str. 297-300. https://hrcak.srce.hr/78828. Citirano 17.11.2019.
Chicago 17th Edition
Vilibić-Čavlek, Tatjana, Sunčanica Ljubin-Sternak, Gordana Vojnović, Mario Sviben i Gordana Mlinarić-Galinović. "The Role of IgG Avidity in Diagnosis of Cytomegalovirus Infection in Newborns and Infants." Collegium antropologicum 36, br. 1 (2012): 297-300. https://hrcak.srce.hr/78828
Harvard
Vilibić-Čavlek, T., et al. (2012). 'The Role of IgG Avidity in Diagnosis of Cytomegalovirus Infection in Newborns and Infants', Collegium antropologicum, 36(1), str. 297-300. Preuzeto s: https://hrcak.srce.hr/78828 (Datum pristupa: 17.11.2019.)
Vancouver
Vilibić-Čavlek T, Ljubin-Sternak S, Vojnović G, Sviben M, Mlinarić-Galinović G. The Role of IgG Avidity in Diagnosis of Cytomegalovirus Infection in Newborns and Infants. Collegium antropologicum [Internet]. 2012 [pristupljeno 17.11.2019.];36(1):297-300. Dostupno na: https://hrcak.srce.hr/78828
IEEE
T. Vilibić-Čavlek, S. Ljubin-Sternak, G. Vojnović, M. Sviben i G. Mlinarić-Galinović, "The Role of IgG Avidity in Diagnosis of Cytomegalovirus Infection in Newborns and Infants", Collegium antropologicum, vol.36, br. 1, str. 297-300, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/78828. [Citirano: 17.11.2019.]

Sažetak
To evaluate the value of IgG avidity in diagnosis of congenital cytomegalovirus (CMV) infection in newborns and infants we collected serum samples from 40 infants under 12 months of age with suspected congenital CMV infection. Sera were tested for IgM, IgG and IgG avidity. For 25 of them, virus isolation and/or polymerase chain reaction (PCR) on urine specimens were performed. Thirteen (32.5%) patients showed the presence of CMV IgM antibodies, 3 (7.5%) had equivocal IgM result, and 24 (60.0%) patients had IgG antibodies only. Using IgG avidity, CMV infection (low avidity index- AI) was documented in 61.5% IgM positive and 54.2% IgM negative patients. Eight of nine (88.8%) IgM positive patients were positive either on virus isolation or PCR. In IgM negative patients, 46.6% urine cultures were positive for CMV and 66.6% were PCR positive. According to age, IgG avidity demonstrated acute/recent primary CMV infection in 58.8% patients younger than three months compared with 91.7% and 81.8% in 3–6 and 6–12 months old babies, respectively. In conclusion, IgG avidity is useful in diagnosis of CMV infection either in IgM positive or IgM negative children older than 3 months of age. In infants less than 3 months, transplacentally derived maternal IgG antibodies of high avidity influence on the IgG avidity result. In these children, CMV infection should be confirmed by direct virologic methods such as virus isolation or PCR.

Ključne riječi
CMV; diagnosis; IgG avidity; newborns; infants

Hrčak ID: 78828

URI
https://hrcak.srce.hr/78828

Posjeta: 407 *