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https://doi.org/10.5562/cca1770

Extractive Spectrophotometric Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine

Nagaraju Rajendraprasad ; Department of Chemistry, University of Mysore, Manasagangothri, Mysore 570 006, India
Kanakapura Basavaiah ; Department of Chemistry, University of Mysore, Manasagangothri, Mysore 570 006, India
Kanakapura Basavaiah Vinay ; Department of Chemistry, University of Mysore, Manasagangothri, Mysore 570 006, India

Puni tekst: engleski, pdf (1 MB) str. 9-17 preuzimanja: 1.258* citiraj
APA 6th Edition
Rajendraprasad, N., Basavaiah, K. i Vinay, K.B. (2012). Extractive Spectrophotometric Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine. Croatica Chemica Acta, 85 (1), 9-17. https://doi.org/10.5562/cca1770
MLA 8th Edition
Rajendraprasad, Nagaraju, et al. "Extractive Spectrophotometric Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine." Croatica Chemica Acta, vol. 85, br. 1, 2012, str. 9-17. https://doi.org/10.5562/cca1770. Citirano 05.03.2021.
Chicago 17th Edition
Rajendraprasad, Nagaraju, Kanakapura Basavaiah i Kanakapura Basavaiah Vinay. "Extractive Spectrophotometric Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine." Croatica Chemica Acta 85, br. 1 (2012): 9-17. https://doi.org/10.5562/cca1770
Harvard
Rajendraprasad, N., Basavaiah, K., i Vinay, K.B. (2012). 'Extractive Spectrophotometric Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine', Croatica Chemica Acta, 85(1), str. 9-17. https://doi.org/10.5562/cca1770
Vancouver
Rajendraprasad N, Basavaiah K, Vinay KB. Extractive Spectrophotometric Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine. Croatica Chemica Acta [Internet]. 2012 [pristupljeno 05.03.2021.];85(1):9-17. https://doi.org/10.5562/cca1770
IEEE
N. Rajendraprasad, K. Basavaiah i K.B. Vinay, "Extractive Spectrophotometric Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine", Croatica Chemica Acta, vol.85, br. 1, str. 9-17, 2012. [Online]. https://doi.org/10.5562/cca1770

Sažetak
A simple, sensitive and selective extractive spectrophotometric method for the determination of quetiapine fumarate (QTF) in bulk drug, tablets and spiked human urine sample is described. The method is based on the formation of a chloroform extractable yellow ion-pair complex between basic nitrogen of the drug (QTF) and the dye quinoline yellow (QY) in acetate-hydrochloride buffer (pH 2.56) medium. The formed ion-pair complex exhibited an absorption maximum at 420 nm. Beer’s law is obeyed over the concentration range 2.5–25 µg mL–1 with an apparent molar absorptivity value of 2.02 × 104 L mol–1 cm–1. The Sandell sensitivity, limits of detection (LOD) and quantification values are also reported. The composition of the ion-pair was established by Job’s continuous variations method and it was found to be 1:1 (QTF:QY). The proposed method was successfully applied for the determination of QTF in bulk drug, tablets and spiked human urine without any interference. (doi: 10.5562/cca1770)

Ključne riječi
quetiapine fumarate; determination; spectrophotometry; quinoline yellow; pharmaceuticals

Hrčak ID: 80393

URI
https://hrcak.srce.hr/80393

Posjeta: 1.719 *