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https://doi.org/10.2478/v10007-012-0028-8

A compressibility and compactibility study of real tableting mixtures: The effect of granule particle size

MAJA ŠANTL ; Krka, d.d., Novo mesto, 8501 Novo mesto, Slovenia
ILIJA ILIĆ ; Faculty of Pharmacy, 1000 Ljubljana, Slovenia
FRANC VREČER ; Krka, d.d., Novo mesto, 8501 Novo mesto, Slovenia; Faculty of Pharmacy, 1000 Ljubljana, Slovenia
SAŠA BAUMGARTNER ; Faculty of Pharmacy, 1000 Ljubljana, Slovenia

Puni tekst: engleski, pdf (229 KB) str. 325-340 preuzimanja: 7.246* citiraj
APA 6th Edition
ŠANTL, M., ILIĆ, I., VREČER, F. i BAUMGARTNER, S. (2012). A compressibility and compactibility study of real tableting mixtures: The effect of granule particle size. Acta Pharmaceutica, 62 (3), 325-340. https://doi.org/10.2478/v10007-012-0028-8
MLA 8th Edition
ŠANTL, MAJA, et al. "A compressibility and compactibility study of real tableting mixtures: The effect of granule particle size." Acta Pharmaceutica, vol. 62, br. 3, 2012, str. 325-340. https://doi.org/10.2478/v10007-012-0028-8. Citirano 21.01.2020.
Chicago 17th Edition
ŠANTL, MAJA, ILIJA ILIĆ, FRANC VREČER i SAŠA BAUMGARTNER. "A compressibility and compactibility study of real tableting mixtures: The effect of granule particle size." Acta Pharmaceutica 62, br. 3 (2012): 325-340. https://doi.org/10.2478/v10007-012-0028-8
Harvard
ŠANTL, M., et al. (2012). 'A compressibility and compactibility study of real tableting mixtures: The effect of granule particle size', Acta Pharmaceutica, 62(3), str. 325-340. https://doi.org/10.2478/v10007-012-0028-8
Vancouver
ŠANTL M, ILIĆ I, VREČER F, BAUMGARTNER S. A compressibility and compactibility study of real tableting mixtures: The effect of granule particle size. Acta Pharm. [Internet]. 2012 [pristupljeno 21.01.2020.];62(3):325-340. https://doi.org/10.2478/v10007-012-0028-8
IEEE
M. ŠANTL, I. ILIĆ, F. VREČER i S. BAUMGARTNER, "A compressibility and compactibility study of real tableting mixtures: The effect of granule particle size", Acta Pharmaceutica, vol.62, br. 3, str. 325-340, 2012. [Online]. https://doi.org/10.2478/v10007-012-0028-8

Sažetak
This study investigates the effect of particle size on the compression characteristics of wet- (fluid-bed granulation – FBG) and dry-granulated (slugging – DGS) tableting mixtures. Particle-size distribution, flowability, compressibility, using the Heckel and Walker model, compactibility and elastic recovery as well as friability and disintegration were determined and compared between the two particle size fractions (180400 µm, 400710 µm) and initial unsieved mixtures. The results showed that the particle size of granules had no effect on the compressibility of the FBG and DGS mixtures, due to the high fragmenting nature of the formulation used in this study. On the other hand, compactibility was particle size dependent, as larger-sized fractions showed higher crushing strength, lower friability, and lower elastic recovery. This was attributed to increased fragmentation of larger particles, allowing stronger bonding between uncontaminated surface areas. As a result of better rearrangement of particles, both initial tableting mixtures showed lower compressibility and lower compactibility compared to their sieved fractions.

Ključne riječi
particle size; compressibility; compactibility; Heckel, Walker

Hrčak ID: 81779

URI
https://hrcak.srce.hr/81779

[slovenski]

Posjeta: 7.707 *