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Stručni rad
https://doi.org/10.2478/10004-1254-63-2012-2213

Genotoxicity of Metal Nanoparticles: Focus on In-vivo Studies

Katharina Klien ; Institute for Occupational Medicine, Medical University of Vienna, Vienna, Austria
Jasminka Godnić-Cvar ; Institute for Occupational Medicine, Medical University of Vienna, Vienna, Austria

Puni tekst: engleski, pdf (116 KB) str. 133-144 preuzimanja: 2.031* citiraj
APA 6th Edition
Klien, K. i Godnić-Cvar, J. (2012). Genotoxicity of Metal Nanoparticles: Focus on In-vivo Studies. Arhiv za higijenu rada i toksikologiju, 63 (2), 133-144. https://doi.org/10.2478/10004-1254-63-2012-2213
MLA 8th Edition
Klien, Katharina i Jasminka Godnić-Cvar. "Genotoxicity of Metal Nanoparticles: Focus on In-vivo Studies." Arhiv za higijenu rada i toksikologiju, vol. 63, br. 2, 2012, str. 133-144. https://doi.org/10.2478/10004-1254-63-2012-2213. Citirano 16.09.2019.
Chicago 17th Edition
Klien, Katharina i Jasminka Godnić-Cvar. "Genotoxicity of Metal Nanoparticles: Focus on In-vivo Studies." Arhiv za higijenu rada i toksikologiju 63, br. 2 (2012): 133-144. https://doi.org/10.2478/10004-1254-63-2012-2213
Harvard
Klien, K., i Godnić-Cvar, J. (2012). 'Genotoxicity of Metal Nanoparticles: Focus on In-vivo Studies', Arhiv za higijenu rada i toksikologiju, 63(2), str. 133-144. https://doi.org/10.2478/10004-1254-63-2012-2213
Vancouver
Klien K, Godnić-Cvar J. Genotoxicity of Metal Nanoparticles: Focus on In-vivo Studies. Arh Hig Rada Toksikol. [Internet]. 2012 [pristupljeno 16.09.2019.];63(2):133-144. https://doi.org/10.2478/10004-1254-63-2012-2213
IEEE
K. Klien i J. Godnić-Cvar, "Genotoxicity of Metal Nanoparticles: Focus on In-vivo Studies", Arhiv za higijenu rada i toksikologiju, vol.63, br. 2, str. 133-144, 2012. [Online]. https://doi.org/10.2478/10004-1254-63-2012-2213

Sažetak
With increasing production and application of a variety of nanomaterials (NMs), research on their cytotoxic and genotoxic potential grows, as the exposure to these nano-sized materials may potentially result in adverse health effects. In large part, indications for potential DNA damaging effects of nanoparticles (NPs) originate from inconsistent in vitro studies. To clarify these effects, the implementation of in vivo studies has been emphasised. This paper summarises study results of genotoxic effects of NPs, which are available in the recent literature. They provide indications that some NP types cause both DNA strand breaks and chromosomal damages in experimental animals. Their genotoxic effects, however, do not depend only on particle size, surface modifi cation (particle coating), and exposure route, but also on exposure duration. Currently available animal studies may suggest differing mechanisms (depending on the duration of exposure) by which living organisms react to NP contact. Nevertheless, due to considerable inconsistencies in the recent literature and the lack of standardised test methods - a reliable hazard assessment of NMs is still limited. Therefore, international organisations (e.g. NIOSH) suggest utmost caution when potential exposure of humans to NMs occurs, as long as evidence of their toxicological and genotoxic effect(s) is limited.

Ključne riječi
adverse health effects; chromosomal damage; coating; DNA damage; nanomaterials; rodents

Hrčak ID: 83244

URI
https://hrcak.srce.hr/83244

[hrvatski]

Posjeta: 2.329 *