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Histologic Subtypes of Invasive Lobular Carcinoma in Correlation with Tumor Status and Hormone Receptors

Ivana Miše
Majda Vučić
Ivana Maričević
Marijka Šokčević
Silva Čurić-Jurić

Puni tekst: engleski, pdf (169 KB) str. 275-281 preuzimanja: 466* citiraj
APA 6th Edition
Miše, I., Vučić, M., Maričević, I., Šokčević, M. i Čurić-Jurić, S. (2010). Histologic Subtypes of Invasive Lobular Carcinoma in Correlation with Tumor Status and Hormone Receptors. Acta clinica Croatica, 49 (3), 275-281. Preuzeto s https://hrcak.srce.hr/84723
MLA 8th Edition
Miše, Ivana, et al. "Histologic Subtypes of Invasive Lobular Carcinoma in Correlation with Tumor Status and Hormone Receptors." Acta clinica Croatica, vol. 49, br. 3, 2010, str. 275-281. https://hrcak.srce.hr/84723. Citirano 13.11.2019.
Chicago 17th Edition
Miše, Ivana, Majda Vučić, Ivana Maričević, Marijka Šokčević i Silva Čurić-Jurić. "Histologic Subtypes of Invasive Lobular Carcinoma in Correlation with Tumor Status and Hormone Receptors." Acta clinica Croatica 49, br. 3 (2010): 275-281. https://hrcak.srce.hr/84723
Harvard
Miše, I., et al. (2010). 'Histologic Subtypes of Invasive Lobular Carcinoma in Correlation with Tumor Status and Hormone Receptors', Acta clinica Croatica, 49(3), str. 275-281. Preuzeto s: https://hrcak.srce.hr/84723 (Datum pristupa: 13.11.2019.)
Vancouver
Miše I, Vučić M, Maričević I, Šokčević M, Čurić-Jurić S. Histologic Subtypes of Invasive Lobular Carcinoma in Correlation with Tumor Status and Hormone Receptors. Acta clinica Croatica [Internet]. 2010 [pristupljeno 13.11.2019.];49(3):275-281. Dostupno na: https://hrcak.srce.hr/84723
IEEE
I. Miše, M. Vučić, I. Maričević, M. Šokčević i S. Čurić-Jurić, "Histologic Subtypes of Invasive Lobular Carcinoma in Correlation with Tumor Status and Hormone Receptors", Acta clinica Croatica, vol.49, br. 3, str. 275-281, 2010. [Online]. Dostupno na: https://hrcak.srce.hr/84723. [Citirano: 13.11.2019.]

Sažetak
Invasive lobular carcinoma is a distinct biological entity with several histologic variants the prognostic value of which is not fully elucidated. The aim of this study was to determine the immunohistochemical expression of estrogen receptors (ER ) and progedterone receptors (PR) in subtypes of lobular breast carcinoma (classic and variant types) and to correlate them with clinical and tumor parameters. Fifty lobular carcinomas, i.e. 33 classic and 17 variant, were analyzed. The classic type was more common (66%) and found in older women (61 years of age), smaller in size (1.5 cm), with N0 status and modestly positive ER and PR. The variant types were more frequent in younger women (55 years of age), larger in size (2.5 cm), with N1 status and maximal positive ER and PR. ER was expressed in 82% and PR in 78% of all tumors, mostly with maximal expression. Only one tumor of the classic type was HER /2neu 3+, ER and PR-. ER expression was significantly associated with a decreased incidence of other proliferative lesions (p=0.043). The total sample and the classic type were characterized by a significant positive correlation between ER and PR (p=0.004) and between tumor size and N status (p=0.005), and by negative correlation between HER /2neu and N status (p=0.042). In variant types, larger tumors were related to higher N (p=0.021), while higher ER expression was associated with smaller tumors (p=0.044). The study indicated distinct biological features of lobular carcinoma subtypes and the need for a more selective therapeutic approach.

Ključne riječi
Breast neoplasms – diagnosis; Breast neoplasms – pathology; Carcinoma, lobular – diagnosis; Carcinoma, lobular – pathology; Neoplasm staging; Aged; Female

Hrčak ID: 84723

URI
https://hrcak.srce.hr/84723

[hrvatski]

Posjeta: 998 *