Izvorni znanstveni članak
The Influence of Clinical and Anthropometric Parameters on the Serum Levels of the Endothelin-1 in Pregnant Women and their Newborns
Alenka Vukelić Šarunić
Olga Cvijanović
Luka Đudarić
Branko Denona
Lucian Vukelić
Dragica Bobinac
Aleks Finderle
Sažetak
Pregnancy induced hypertension (PIH) is major contributor to maternal death in developing countries. Endothelin-1
(ET-1) is the most potent vasoconstriction agent known and its serum levels are increased in PIH. Therefore it is important
to elucidate maternal and neonatal factors which influence endothelin-1 serum levels. 100 pathological pregnancies
and 88 controls were analyzed for blood endothelin-1 and their anthropometric and clinical data were collected. In maternal
blood ET-1 levels were strongly predicted by diagnosis, therapy and BMI, while umbilical cord ET-1 levels were
strongly predicted by gestational age, therapy and delivery termination. Positive correlation between BMI and ET-1 levels
suggest that obese pregnant women have increased risk for cardiovascular diseases. Inverse relationship between
Apgar and umbilical ET-1 indicates that ET-1 could be considered as a prognostic marker in cases of neonatal asphyxia.
Ključne riječi
endothelin-1; pregnancy induced hypertension; anthropometry; apgar
Hrčak ID:
84775
URI
Datum izdavanja:
10.7.2012.
Posjeta: 839 *