Izvorni znanstveni članak
Polymorphisms of Vitamin D Receptor Gene in the Population of Eastern Croatia with Psoriasis vulgaris and Diabetes mellitus
Melita Vukšić Polić
Ivana Ručević
Vladimira Barišić-Druško
Maja Miškulin
Ljubica Glavaš-Obrovac
Mario Štefanić
Ivan Karner
Jasna Lipozenčić
Tatjana Bačun
Ivan Mihaljević
Sažetak
The aim of this study was to evaluate the possible association between polymorphisms in the Vitamin D receptor gene
(VDR gene) and tendency for development of psoriasis vulgaris and diabetes mellitus in the population of Slavonia,
which is a region in the Eastern Croatia. In order to conduct the mentioned evaluation the restriction fragment length
polymorphisms (ApaI, BsmI and TaqI) in the Vitamin D receptor gene were researched in three groups of patients: patients
suffering only from psoriasis vulgaris, patients suffering only from diabetes mellitus, and patients suffering at the
same time from both diseases. Four most common genotypes were found in all standardized control patients: triple heterozygotes
BbAaTt (in 29.3% of the studied patients), bbAaTT (in 18.6% of the studied patients), bbaaTT (in 12.9% of the
studied patients) and BbAATt (in 8.6% of the studied patients). Three most common VDR 3’-RFLP haplotypes determined
in this study were: three-component baT, Bat and bAT haplotype. Results of the Hardy-Weinberg equilibrium
showed presence of BsmI polymorphism genotype frequencies disequilibrium in the group of patients suffering from psoriasis
and ApaI polymorphism in the group of patients suffering from both diseases. According to the same statistical test
all conditions for TaqI polymorphism genotype frequency were fulfilled in all groups of studied patients. There was no
significant difference in distribution of BsmI, ApaI or TaqI polymorphism genotype frequencies between control patients
and any of the subgroup of studied patients. In studied population none of analysed polymorphisms individually was associated
with the risk of development of psoriasis, diabetes or combined phenotype.
Ključne riječi
psoriasis vulgaris; diabetes mellitus; Vitamin D receptor gene polymorphisms
Hrčak ID:
84789
URI
Datum izdavanja:
10.7.2012.
Posjeta: 1.267 *