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Polymorphisms of Vitamin D Receptor Gene in the Population of Eastern Croatia with Psoriasis vulgaris and Diabetes mellitus

Melita Vukšić Polić
Ivana Ručević
Vladimira Barišić-Druško
Maja Miškulin
Ljubica Glavaš-Obrovac
Mario Štefanić
Ivan Karner
Jasna Lipozenčić
Tatjana Bačun
Ivan Mihaljević

Puni tekst: engleski, pdf (86 KB) str. 451-457 preuzimanja: 417* citiraj
APA 6th Edition
Vukšić Polić, M., Ručević, I., Barišić-Druško, V., Miškulin, M., Glavaš-Obrovac, Lj., Štefanić, M., ... Mihaljević, I. (2012). Polymorphisms of Vitamin D Receptor Gene in the Population of Eastern Croatia with Psoriasis vulgaris and Diabetes mellitus. Collegium antropologicum, 36 (2), 451-457. Preuzeto s https://hrcak.srce.hr/84789
MLA 8th Edition
Vukšić Polić, Melita, et al. "Polymorphisms of Vitamin D Receptor Gene in the Population of Eastern Croatia with Psoriasis vulgaris and Diabetes mellitus." Collegium antropologicum, vol. 36, br. 2, 2012, str. 451-457. https://hrcak.srce.hr/84789. Citirano 12.12.2019.
Chicago 17th Edition
Vukšić Polić, Melita, Ivana Ručević, Vladimira Barišić-Druško, Maja Miškulin, Ljubica Glavaš-Obrovac, Mario Štefanić, Ivan Karner, Jasna Lipozenčić, Tatjana Bačun i Ivan Mihaljević. "Polymorphisms of Vitamin D Receptor Gene in the Population of Eastern Croatia with Psoriasis vulgaris and Diabetes mellitus." Collegium antropologicum 36, br. 2 (2012): 451-457. https://hrcak.srce.hr/84789
Harvard
Vukšić Polić, M., et al. (2012). 'Polymorphisms of Vitamin D Receptor Gene in the Population of Eastern Croatia with Psoriasis vulgaris and Diabetes mellitus', Collegium antropologicum, 36(2), str. 451-457. Preuzeto s: https://hrcak.srce.hr/84789 (Datum pristupa: 12.12.2019.)
Vancouver
Vukšić Polić M, Ručević I, Barišić-Druško V, Miškulin M, Glavaš-Obrovac Lj, Štefanić M i sur. Polymorphisms of Vitamin D Receptor Gene in the Population of Eastern Croatia with Psoriasis vulgaris and Diabetes mellitus. Collegium antropologicum [Internet]. 2012 [pristupljeno 12.12.2019.];36(2):451-457. Dostupno na: https://hrcak.srce.hr/84789
IEEE
M. Vukšić Polić, et al., "Polymorphisms of Vitamin D Receptor Gene in the Population of Eastern Croatia with Psoriasis vulgaris and Diabetes mellitus", Collegium antropologicum, vol.36, br. 2, str. 451-457, 2012. [Online]. Dostupno na: https://hrcak.srce.hr/84789. [Citirano: 12.12.2019.]

Sažetak
The aim of this study was to evaluate the possible association between polymorphisms in the Vitamin D receptor gene
(VDR gene) and tendency for development of psoriasis vulgaris and diabetes mellitus in the population of Slavonia,
which is a region in the Eastern Croatia. In order to conduct the mentioned evaluation the restriction fragment length
polymorphisms (ApaI, BsmI and TaqI) in the Vitamin D receptor gene were researched in three groups of patients: patients
suffering only from psoriasis vulgaris, patients suffering only from diabetes mellitus, and patients suffering at the
same time from both diseases. Four most common genotypes were found in all standardized control patients: triple heterozygotes
BbAaTt (in 29.3% of the studied patients), bbAaTT (in 18.6% of the studied patients), bbaaTT (in 12.9% of the
studied patients) and BbAATt (in 8.6% of the studied patients). Three most common VDR 3’-RFLP haplotypes determined
in this study were: three-component baT, Bat and bAT haplotype. Results of the Hardy-Weinberg equilibrium
showed presence of BsmI polymorphism genotype frequencies disequilibrium in the group of patients suffering from psoriasis
and ApaI polymorphism in the group of patients suffering from both diseases. According to the same statistical test
all conditions for TaqI polymorphism genotype frequency were fulfilled in all groups of studied patients. There was no
significant difference in distribution of BsmI, ApaI or TaqI polymorphism genotype frequencies between control patients
and any of the subgroup of studied patients. In studied population none of analysed polymorphisms individually was associated
with the risk of development of psoriasis, diabetes or combined phenotype.

Ključne riječi
psoriasis vulgaris; diabetes mellitus; Vitamin D receptor gene polymorphisms

Hrčak ID: 84789

URI
https://hrcak.srce.hr/84789

Posjeta: 581 *