Sažetak Erectile dysfunction (ED) is the inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse. Erectile dysfunction is a growing health problem that adversely affects the person’s sense of health and quality of life and disrupts relationships between partners. It is believed that more than half of men aged 40-70 years and more than a third of women of all ages suffer from ED either continuously or intermittently. Better treatment options, new knowledge about the disease and public information campaigns have not only increased the number of visits, but also the number of newly diagnosed patients with ED. The article presents the aetiology, pathogenesis, diagnosis and current recommendations for ED treatment. Over the past decades, expert opinion on the causes of impotence has changed. Today, it is considered that ED is not a disease, but one of the very early symptoms of cardiovascular disease, in most cases caused by organic changes. Decision on the diagnosis and treatment of ED requires a multidisciplinary approach and cooperation of urologists, cardiologists, endocrinologists, infectious disease specialists, gynaecologists and psychiatrists.