Sažetak Genital human papillomavirus (HPV) infections are among the most common sexually transmitted diseases. Over 100 distinct HPVs have been identified and each is associated with a specific set of clinical lesions. They cause a wide spectrum of diseases, from benign verrucae vulgares and condylomata acuminata to the malignancies of the cervix, vulva, vagina, penis and anus. Diseases associated with HPV infection can be divided to skin and mucosal lesion of genital and extragenital region. Other HPV-associated diseases include melanoma, non-melanoma skin cancer, actinic and seborrhoeic keratosis, epidermal cyst, extragenital Bowen’s disease, Paget’s disease, invasive breast cancer, and lichen sclerosus psoriatic plaque. Cutaneous HPV can even be found on healthy skin previously exposed to artificial UV radiation.