Ostalo
From Circumscribed Scleroderma (Morphea) to Subcutaneous Panniculitis-Like T-Cell Lymphoma: Case Report
Nina Troskot
; Department of Dermatology and Venerology, Sestre milosrdnice University Hospital, Zagreb, Croatia
Liborija Lugović
; Department of Dermatology and Venerology, Sestre milosrdnice University Hospital, Zagreb, Croatia
Mirna Šitum
; Department of Dermatology and Venerology, Sestre milosrdnice University Hospital, Zagreb, Croatia
Majda Vučić
; Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital, Zagreb, Croatia
Sažetak
Subcutaneous panniculitis-like T-cell lymphoma is a rare form
of non-Hodgkin lymphoma. It presents clinically as panniculitis, with
erythematous, firm subcutaneous infiltrates and recurrent papulonodules.
A 45-year-old male Croat presented with a 6-month history of tender
erythematous subcutaneous skin lesions without systemic symptoms.
Analysis of a lesion biopsy specimen showed circum scribed scleroderma
(morphea). During hospitalization, skin biopsies from two subcutaneous lesions on the stom ach were repeated, and pathohistologic analysis corresponded primarily to panniculitis in the context of morphea. Pathohistologic
analysis and immunohistochemistry of a specimen obtained by tumor ex cision from the back indicated subcutaneous panniculitis-like T-cell lymphoma. Histologic analysis re vealed a dense infiltrate of atypical T-lymphoid cells expressing CD8+ phenotype located in the subcutaneous tissue with histiocyte-phagocytizing apoptotic cells. Specific hematologic
analysis and medical treatment were continued. This case report illustrates
the importance of continuous follow-up with repeat biopsy and use of
immunohistologic techniques for early diagnosis.
Ključne riječi
subcutaneous panniculitis-like T-cell lymphoma; circumscribed scleroderma; morphea; immunohistochemistry
Hrčak ID:
88555
URI
Datum izdavanja:
1.4.2004.
Posjeta: 1.004 *