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Gastroesophageal Reflux Disease Accompanying Urticaria Pigmentosa

Magdalena Reich ; Department of Dermatology, Venereology and Allergology Wroclaw Medical University
Adam Reich
Marta Rzeszutko
Barbara Iwańczak

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Sažetak
A few case reports have only been published to date,
which show the possible link between mastocytosis and gastroesophageal
reflux disease (GERD). Here, we present a 17-month-old boy with
urticaria pigmentosa who also suffered from GERD. First skin lesions
accompanied by gastrointestinal symptoms (regurgitations, appetite
worsening) were noticed at the age of four months. At that time, they
were misdiagnosed as symptoms of cow’s milk allergy. Despite the
cow’s milk-free diet, the skin and gastrointestinal symptoms slowly
worsened and the patient was referred to us for further diagnostics
several months later. Based on the clinical presentation of skin lesions,
presence of pruritus and positive Darier’s sign, cutaneous mastocytosis
was diagnosed; 24-hour pH-metry revealed an increased number
of acidic refluxes and biopsy of duodenal mucosa showed numerous
mast cells. Taking into account these findings, the gastrointestinal
symptoms were supposed to be a manifestation of mastocytosis. Treatment
with sodium cromoglycate, cetirizine, ranitidine and probiotics
resulted in pruritus alleviation, improvement of appetite and sleeping
as well as increase of body weight.

Ključne riječi
mastocytosis; urticaria pigmentosa; gastroesophageal reflux

Hrčak ID: 89055

URI
https://hrcak.srce.hr/89055

Posjeta: 159 *