Ostalo
Detection of Plasma and Urinary Monoamines and Their Metabolites in Nonsegmental Vitiligo
Zeinab Shahin
; Dermatology Department
Tahra M Leheta
; Dermatology Department
Rania M Abdel Hay
; 13th Abrag Othman, kornish El Maadi Cairo, Egypt (11431)
Hanaa M Abdel Aal
; Dermatology Department
Laila A Rashed
; Dermatology Department
Sažetak
Vitiligo is one of the most troubling diseases to both patient and
physician. Monoamines are chemical compounds derived from the hydroxyderivative
of amino acids. They have been implicated in many dermatoses,
but their role in the etiopathogenesis of vitiligo remains obscure. The aim of
the study was to evaluate the role of the neural factor in the pathogenesis
of nonsegmental vitiligo (NSV) by measuring catecholamines and their metabolites
in plasma and urine of patients suffering from NSV, and to correlate
these factors with the onset and activity of the disease. The study included
20 patients with NSV and 20 healthy individuals. All subjects were subjected
to plasma and urine detection of catecholamines and 5-hydroxyindoleacetic
acid (5-HIAA) using high-performance liquid chromatography and electrochemical
detection. Comparison of plasma and urinary catecholamines and
5-HIAA between the patient and control groups revealed a statistically significant
increase in the group of NSV patients (P<0.05). There was no statistically
significant difference (P>0.05) between the patients with recent and old
onset of NSV. In conclusion, the increase in the level of monoamines may be
the initiating event in the pathogenesis of NSV.
Ključne riječi
catecholamines; monoamines; vitiligo
Hrčak ID:
89077
URI
Datum izdavanja:
16.4.2012.
Posjeta: 423 *