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Penile Cutaneous Horn Ten Years after Treatment of Verrucous Squamous Cell Carcinoma on Penile Glans: Case Report

Ivica Mokos ; University Hospital Center Zagreb Department of Urology Kišpatićeva 12 HR-10000 Zagreb Croatia
Zrinka Bukvić Mokos ; Department of Dermatology and Venereology
Suzana Ljubojević ; Department of Dermatology and Venereology
Marijana Ćorić ; Department of Pathology, University Hospital Center Zagreb and School of Medicine, Zagreb, Croatia
Magdalena Grce ; Laboratory of Molecular Virology and Bacteriology, Division of Molecular Medicine, Ruđer Bošković Institute, Zagreb, Croatia
Michal Michal ; Department of Pathology, Charles University, Medical Faculty Hospital, Pilsen, Czech Republic

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Sažetak
Penile cutaneous horn is a clinical term that describes protruding
hyperkeratosis, usually conical in shape, located on penile glans. Penile
localization of this lesion, predominantly located on sun-exposed areas, is
very rare. The association with malignancy on the penis makes proper identification
of these lesions essential. We present a 45-year-old man with a cutaneous
horn, 25 mm in size, located on the basis of penile glans. The patient
had a history of phimosis, pseudoepitheliomatous balanoposthitis, surgical
excision of penile verrucous squamous cell carcinoma (SCC) and postoperative
radiotherapy of carcinoma in situ on the same localization, ten years before.
Complete surgical removal of the horn with separate excision of the
margins and base was done. Pathologic examination revealed squamous
hyperplasia with suspicion of carcinoma in situ. Additional negative p16INK4a
immunohistochemical analysis confirmed benign proliferative lesion. DNA
polymerase chain reaction for human papilloma virus infection was negative.
These findings suggested sparing surgical procedure in our patient, without
indication for partial penile amputation, but with mandatory follow-up. Our
case confirmed the association of pseudoepitheliomatous balanoposthitis
with verrucous SCC, as well as the possible influence of radiotherapy on the
development of penile cutaneous horn. Additionally, we showed the important
role p16INK4a immunohistochemical analysis in the differential diagnosis
of alterations adjacent to invasive SCC of the penis.

Ključne riječi
penile horn; penile carcinoma; p16INK4a

Hrčak ID: 89080

URI
https://hrcak.srce.hr/89080

Posjeta: 171 *