Pregledni rad

PARANEOPLASTIC LIMBIC ENCEPHALITIS

VIŠNJA NESEK ADAM ; Klinika za anesteziologiju, reanimatologiju i intenzivno liječenje, Klinika za neurologiju, Klinička bolnica “Sveti Duh”, Zagreb, Hrvatska
DAMJAN MARIN ; Klinika za anesteziologiju, reanimatologiju i intenzivno liječenje, Klinika za neurologiju, Klinička bolnica “Sveti Duh”, Zagreb, Hrvatska
HRVOJE BUDINČEVIĆ ; Klinika za neurologiju, Klinička bolnica “Sveti Duh”, Zagreb, Hrvatska
VIVIANA MRŠIĆ ; Klinika za anesteziologiju, reanimatologiju i intenzivno liječenje, Klinika za neurologiju, Klinička bolnica “Sveti Duh”, Zagreb, Hrvatska
TANJA GORANOVIĆ ; Klinika za anesteziologiju, reanimatologiju i intenzivno liječenje, Klinika za neurologiju, Klinička bolnica “Sveti Duh”, Zagreb, Hrvatska
DINKO TONKOVIĆ ; Klinika za anesteziologiju, reanimatologiju i intenzivno liječenje, Klinika za neurologiju, Klinička bolnica “Sveti Duh”, Zagreb, Hrvatska

Sažetak

Paraneoplastic limbic encephalitis (PLE) is a condition characterized by nervous system damage or dysfunction without indication that the nervous system is directly affected by tumor cells. Since it is clinically presented with an array of neuropsychiatric symptoms that usually precede the occurrence of malignant disease; and because of mimicking a psychiatric disease; it can
sometimes make the diagnosis difficult and can be overlooked. Typical presentations consist of progressive confusion and deficits in short-term memory; which worsen over days to weeks. The current hypothesis on the pathogenesis of PLE implicates an autoimmune process involving antigens shared by tumor cells and neuronal cells in limbic structures. It has been considered that
the autoantibodies cross-react with antigens on normal cells such as the neurons; resulting in cytotoxicity; or they can form complexes with a circulating antigen to induce organ damage through immune complex deposition. The treatment of PLE involves underlying cancer removal by surgery; chemotherapy; radiotherapy or hormonal treatment; and immunosuppressive therapy. Unfortunately; this therapy combination is still generally unsatisfactory. Although PLE is a relatively rare neurologic disorder; because of its association with malignancies and difficulty in diagnosing; this article gives a brief review of the literature and summarizes current knowledge of this syndrome.

Ključne riječi

encephalitis; paraneoplastic syndrome

Hrčak ID:

93169

URI

https://hrcak.srce.hr/93169

Datum izdavanja:

30.10.2012.

Podaci na drugim jezicima: hrvatski

Posjeta: 5.621 *