hrcak mascot   Srce   HID

Izvorni znanstveni članak
https://doi.org/10.5562/cca2108

High Resolution Structure of the Manganese Derivative of Insulin

Biserka Prugovečki ; Division of General and Inorganic Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia
Ivana Pulić ; Division of General and Inorganic Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia
Martina Toth ; Division of General and Inorganic Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia
Dubravka Matković-Čalogović ; Division of General and Inorganic Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia

Puni tekst: engleski, pdf (3 MB) str. 435-439 preuzimanja: 702* citiraj
APA 6th Edition
Prugovečki, B., Pulić, I., Toth, M. i Matković-Čalogović, D. (2012). High Resolution Structure of the Manganese Derivative of Insulin. Croatica Chemica Acta, 85 (4), 435-439. https://doi.org/10.5562/cca2108
MLA 8th Edition
Prugovečki, Biserka, et al. "High Resolution Structure of the Manganese Derivative of Insulin." Croatica Chemica Acta, vol. 85, br. 4, 2012, str. 435-439. https://doi.org/10.5562/cca2108. Citirano 21.11.2019.
Chicago 17th Edition
Prugovečki, Biserka, Ivana Pulić, Martina Toth i Dubravka Matković-Čalogović. "High Resolution Structure of the Manganese Derivative of Insulin." Croatica Chemica Acta 85, br. 4 (2012): 435-439. https://doi.org/10.5562/cca2108
Harvard
Prugovečki, B., et al. (2012). 'High Resolution Structure of the Manganese Derivative of Insulin', Croatica Chemica Acta, 85(4), str. 435-439. https://doi.org/10.5562/cca2108
Vancouver
Prugovečki B, Pulić I, Toth M, Matković-Čalogović D. High Resolution Structure of the Manganese Derivative of Insulin. Croatica Chemica Acta [Internet]. 2012 [pristupljeno 21.11.2019.];85(4):435-439. https://doi.org/10.5562/cca2108
IEEE
B. Prugovečki, I. Pulić, M. Toth i D. Matković-Čalogović, "High Resolution Structure of the Manganese Derivative of Insulin", Croatica Chemica Acta, vol.85, br. 4, str. 435-439, 2012. [Online]. https://doi.org/10.5562/cca2108

Sažetak
The structure of the human manganese derivative of insulin was determined using the single crystal X-ray diffraction method. Single crystals were grown by the hanging drop vapour diffusion
crystallization method using zinc-free insulin and manganese(II) sulphate monohydrate in citrate buffer at pH = 6.4. It crystallizes in the trigonal system in the space group R3 with the unit cell parameters: a = b = 81.70 Å and c = 33.73 Å. There are two manganese ions per insulin hexamer in the human manganese-insulin derivative. The manganese ions lie on the three-fold crystallographic axis on opposite sides of
the hexamer. Both manganese ions are octahedrally coordinated by three Nε2 atoms from the imidazolyl side chains of three symmetry-related HisB10/HisD10 and three oxygen atoms of three symmetry-related water molecules. The investigated human manganese-insulin derivative adopts the T6 conformation.
(doi: 10.5562/cca2108)

Ključne riječi
insulin derivative; manganese; X-ray structure

Hrčak ID: 93731

URI
https://hrcak.srce.hr/93731

Posjeta: 928 *