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https://doi.org/10.5562/cca2141

Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3,4-Ethylenedioxythiophene

Ivana Stolić ; Department of Chemistry and Biochemistry, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, HR-10000 Zagreb, Croatia
Monika Avdičević ; University Hospital Centre Osijek, Huttlerova 4, HR-31000 Osijek, Croatia
Nikola Bregović ; Division of Physical Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000 Zagreb, Croatia
Ivo Piantanida ; Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, P.O. Box 180, HR-10000 Zagreb, Croatia
Ljubica Glavaš-Obrovac ; University Hospital Centre Osijek, Huttlerova 4, HR-31000 Osijek, Croatia;Faculty of Medicine, J. J. Strossmayer University of Osijek, Huttlerova 4, HR-31000 Osijek, Croatia
Miroslav Bajić   ORCID icon orcid.org/0000-0003-1686-0294 ; Department of Chemistry and Biochemistry, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, HR-10000 Zagreb, Croatia

Puni tekst: engleski, pdf (2 MB) str. 457-467 preuzimanja: 902* citiraj
APA 6th Edition
Stolić, I., Avdičević, M., Bregović, N., Piantanida, I., Glavaš-Obrovac, Lj. i Bajić, M. (2012). Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3,4-Ethylenedioxythiophene. Croatica Chemica Acta, 85 (4), 457-467. https://doi.org/10.5562/cca2141
MLA 8th Edition
Stolić, Ivana, et al. "Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3,4-Ethylenedioxythiophene." Croatica Chemica Acta, vol. 85, br. 4, 2012, str. 457-467. https://doi.org/10.5562/cca2141. Citirano 18.07.2019.
Chicago 17th Edition
Stolić, Ivana, Monika Avdičević, Nikola Bregović, Ivo Piantanida, Ljubica Glavaš-Obrovac i Miroslav Bajić. "Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3,4-Ethylenedioxythiophene." Croatica Chemica Acta 85, br. 4 (2012): 457-467. https://doi.org/10.5562/cca2141
Harvard
Stolić, I., et al. (2012). 'Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3,4-Ethylenedioxythiophene', Croatica Chemica Acta, 85(4), str. 457-467. doi: https://doi.org/10.5562/cca2141
Vancouver
Stolić I, Avdičević M, Bregović N, Piantanida I, Glavaš-Obrovac Lj, Bajić M. Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3,4-Ethylenedioxythiophene. Croatica Chemica Acta [Internet]. 2012 [pristupljeno 18.07.2019.];85(4):457-467. doi: https://doi.org/10.5562/cca2141
IEEE
I. Stolić, M. Avdičević, N. Bregović, I. Piantanida, Lj. Glavaš-Obrovac i M. Bajić, "Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3,4-Ethylenedioxythiophene", Croatica Chemica Acta, vol.85, br. 4, str. 457-467, 2012. [Online]. doi: https://doi.org/10.5562/cca2141

Sažetak
Eight novel diamidino 3,4-ethylenedioxythiophene-2,5-dicarboxanilides (5a–h), obtained by condensation reaction of 3,4-ethylenedioxythiophene-2,5-dicarbonyl chloride and corresponding 3- or 4-aminobenzamidines, were evaluated for interactions with double-stranded DNA and RNA, and their cyto-toxicity was assayed against the panel of human cancer cell lines. All compounds preferentially bind into the minor groove of DNA and had higher affinity for DNA than for RNA. Compounds 5a–h showed a moderate antiproliferative effect toward the panel of seven carcinoma cells line, whereby the highest inhi-bitory potential was displayed by compound 5a with unsubstituted amidino moieties in para position. (doi: 10.5562/cca2141)

Ključne riječi
amide-amidines; 3,4-ethylenedioxythiophene; diarylamidine; DNA/RNA binding; antitumor activity

Hrčak ID: 94443

URI
https://hrcak.srce.hr/94443

Posjeta: 1.154 *