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Review article

Migraine and stroke

DAVID DELLA-MORTE ; Department of Advanced Biotechnologies and Bioimaging, IRCCS San Raffaele Pisana, 00163 Rome, Italy
MICHAEL J. KATSNELSON ; Department of Neurology, Miller School of Medicine, University of Miami, 1120 NW 14th Street, Miami, FL 33136, USA
TATJANA RUNDEK ; Department of Neurology, Miller School of Medicine, University of Miami, CRB13, 1120 NW 14th Street, Miami, FL 33136, USA

Fulltext: english, pdf (268 KB) pages 361-367 downloads: 452* cite
APA 6th Edition
DELLA-MORTE, D., KATSNELSON, M.J. & RUNDEK, T. (2012). Migraine and stroke. Periodicum biologorum, 114 (3), 361-367. Retrieved from
MLA 8th Edition
DELLA-MORTE, DAVID, et al. "Migraine and stroke." Periodicum biologorum, vol. 114, no. 3, 2012, pp. 361-367. Accessed 17 Sep. 2021.
Chicago 17th Edition
DELLA-MORTE, DAVID, MICHAEL J. KATSNELSON and TATJANA RUNDEK. "Migraine and stroke." Periodicum biologorum 114, no. 3 (2012): 361-367.
DELLA-MORTE, D., KATSNELSON, M.J., and RUNDEK, T. (2012). 'Migraine and stroke', Periodicum biologorum, 114(3), pp. 361-367. Available at: (Accessed 17 September 2021)
DELLA-MORTE D, KATSNELSON MJ, RUNDEK T. Migraine and stroke. Periodicum biologorum [Internet]. 2012 [cited 2021 September 17];114(3):361-367. Available from:
D. DELLA-MORTE, M.J. KATSNELSON and T. RUNDEK, "Migraine and stroke", Periodicum biologorum, vol.114, no. 3, pp. 361-367, 2012. [Online]. Available: [Accessed: 17 September 2021]

Migraine is a primary disorder of the brainwith peripheral consequences. The prevalence of migraine is as high as 18% in the general populations. The association between migraine and stroke has been well documented in many case-control and cohort studies. This association has been stronger in patients with migraine with aura compared to migraine without aura and dependent on sex, age, frequency of attacks, and oral contraceptive treatment.
The mechanisms linking migraine to stroke are complex and not
entirely elucidated. Several hypotheses have been proposed to explain this association. In this review we discuss these hypotheses, the epidemiological data, and the role of patent foramen ovale in migraine and stroke. In addition, we discuss the possible role of genetics in the link between migraine and stroke.

migraine; stroke; aura; PFO; epidemiology; genetics

Hrčak ID: 96146


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