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Acta Pharmaceutica, Vol. 63 No. 2, 2013.

Kratko priopćenje
https://doi.org/10.2478/acph-2013-0018

Synthesis and potential cytotoxic activity of some new benzoxazoles, imidazoles, benzimidazoles and tetrazoles

SUBRAMANIYAN ARULMURUGAN ; Research Department of Chemistry, SRM University, Ramapuram, Chennai, Tamil Nadu, India
HELEN P. KAVITHA ; Research Department of Chemistry, SRM University, Ramapuram, Chennai, Tamil Nadu, India

Puni tekst: engleski, pdf (104 KB) str. 253-264 preuzimanja: 570* citiraj
APA 6th Edition
ARULMURUGAN, S. i KAVITHA, H.P. (2013). Synthesis and potential cytotoxic activity of some new benzoxazoles, imidazoles, benzimidazoles and tetrazoles. Acta Pharmaceutica, 63 (2), 253-264. https://doi.org/10.2478/acph-2013-0018
MLA 8th Edition
ARULMURUGAN, SUBRAMANIYAN i HELEN P. KAVITHA. "Synthesis and potential cytotoxic activity of some new benzoxazoles, imidazoles, benzimidazoles and tetrazoles." Acta Pharmaceutica, vol. 63, br. 2, 2013, str. 253-264. https://doi.org/10.2478/acph-2013-0018. Citirano 20.02.2019.
Chicago 17th Edition
ARULMURUGAN, SUBRAMANIYAN i HELEN P. KAVITHA. "Synthesis and potential cytotoxic activity of some new benzoxazoles, imidazoles, benzimidazoles and tetrazoles." Acta Pharmaceutica 63, br. 2 (2013): 253-264. https://doi.org/10.2478/acph-2013-0018
Harvard
ARULMURUGAN, S., i KAVITHA, H.P. (2013). 'Synthesis and potential cytotoxic activity of some new benzoxazoles, imidazoles, benzimidazoles and tetrazoles', Acta Pharmaceutica, 63(2), str. 253-264. doi: https://doi.org/10.2478/acph-2013-0018
Vancouver
ARULMURUGAN S, KAVITHA HP. Synthesis and potential cytotoxic activity of some new benzoxazoles, imidazoles, benzimidazoles and tetrazoles. Acta Pharm. [Internet]. 2013 [pristupljeno 20.02.2019.];63(2):253-264. doi: https://doi.org/10.2478/acph-2013-0018
IEEE
S. ARULMURUGAN i H.P. KAVITHA, "Synthesis and potential cytotoxic activity of some new benzoxazoles, imidazoles, benzimidazoles and tetrazoles", Acta Pharmaceutica, vol.63, br. 2, str. 253-264, 2013. [Online]. doi: https://doi.org/10.2478/acph-2013-0018

Sažetak
The present work deals with the synthesis of some novel heterocyclic compounds such as benzoxazoles 2, 7, 13 and 19, imidazoles 3, 8, 14 and 20, benzimidazole 4, 9, 15 and 21, tetrazoles 10, 16, and 22. The synthesized compounds were characterized by IR, 1H NMR, mass spectrometry and elemental analysis. The compounds were evaluated for cytotoxicity against human cancer cell line such as, MCF-7 (breast cancer) and HT-29 (colon cancer) by MTT assay method. Among the tested compounds, compounds 4,4’-sulfonylbis(N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)aniline (9), N-bis(2-(benzo[d]oxazol-2-yl)ethyl)-6-phenyl-1,3,5-triazine-2,4-diamine (13), N-bis(2-(1H-benzo[d]imidazol-2-yl)ethyl)-6-phenyl-1,3,5-triazine-2,4-diamine (15) and N-tris(2-1H-benzo[d]imidazol-2-yl)ethyl)-1,3,5-triazine-2,4,6-triamine (21) show potent cytotoxicity.

Ključne riječi
benzimidazoles; imidazoles; benzoxazoles; tetrazoles; synthesis; cytotoxicity; MTT assay

Hrčak ID: 97702

URI
https://hrcak.srce.hr/97702

Posjeta: 721 *