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Original scientific paper
https://doi.org/10.2478/acph-2013-0019

Formulation and in vitro evaluation of metformin hydrochloride loaded microspheres prepared with polysaccharide extracted from natural sources

HEMANTA KUMAR SHARMA ; Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786004, Assam, India
SUNITA LAHKAR ; Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786004, Assam, India
LILA KANTA NATH ; Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786004, Assam, India

Fulltext: english, pdf (175 KB) pages 209-222 downloads: 1.251* cite
APA 6th Edition
SHARMA, H.K., LAHKAR, S. & NATH, L.K. (2013). Formulation and in vitro evaluation of metformin hydrochloride loaded microspheres prepared with polysaccharide extracted from natural sources. Acta Pharmaceutica, 63 (2), 209-222. https://doi.org/10.2478/acph-2013-0019
MLA 8th Edition
SHARMA, HEMANTA KUMAR, et al. "Formulation and in vitro evaluation of metformin hydrochloride loaded microspheres prepared with polysaccharide extracted from natural sources." Acta Pharmaceutica, vol. 63, no. 2, 2013, pp. 209-222. https://doi.org/10.2478/acph-2013-0019. Accessed 21 Nov. 2019.
Chicago 17th Edition
SHARMA, HEMANTA KUMAR, SUNITA LAHKAR and LILA KANTA NATH. "Formulation and in vitro evaluation of metformin hydrochloride loaded microspheres prepared with polysaccharide extracted from natural sources." Acta Pharmaceutica 63, no. 2 (2013): 209-222. https://doi.org/10.2478/acph-2013-0019
Harvard
SHARMA, H.K., LAHKAR, S., and NATH, L.K. (2013). 'Formulation and in vitro evaluation of metformin hydrochloride loaded microspheres prepared with polysaccharide extracted from natural sources', Acta Pharmaceutica, 63(2), pp. 209-222. https://doi.org/10.2478/acph-2013-0019
Vancouver
SHARMA HK, LAHKAR S, NATH LK. Formulation and in vitro evaluation of metformin hydrochloride loaded microspheres prepared with polysaccharide extracted from natural sources. Acta Pharm. [Internet]. 2013 [cited 2019 November 21];63(2):209-222. https://doi.org/10.2478/acph-2013-0019
IEEE
H.K. SHARMA, S. LAHKAR and L.K. NATH, "Formulation and in vitro evaluation of metformin hydrochloride loaded microspheres prepared with polysaccharide extracted from natural sources", Acta Pharmaceutica, vol.63, no. 2, pp. 209-222, 2013. [Online]. https://doi.org/10.2478/acph-2013-0019

Abstracts
The present work envisages utilisation of biodegradable and biocompatible material from natural sources for the development of controlled release microspheres of metformin hydrochloride (MetH). Natural polysaccharides extracted from Dillenia indica L. (DI), Abelmoschus esculentus L. (AE) and Bora rice flour were used in fabricating controlled release microspheres. The microspheres were prepared by the emulsion solvent diffusion technique with different proportions of natural materials and were studied for entrapment efficiency, particle size, particle shape, surface morphology, drug excipient compatibility, mucoadhesivity and in vitro release properties. The prepared microspheres showed mucoadhesive properties and controlled release of metformin hydrochloride. The study has revealed that natural materials can be used for formulation of controlled release microspheres and will provide ample opportunities for further study.

Keywords
metformin hydrochloride; Dillenia indica; Abelmoschus esculentus; Bora rice; emulsion solvent diffusion technique; mucoadhesive; microspheres

Hrčak ID: 97698

URI
https://hrcak.srce.hr/97698

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