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Changes of Acid Phosphatase (AP) Activity in Various Clinical Stages of Oral Lichen Planus. I. Changes of Acid Phosphatase Activity in Epithelial Cells
Marinka Mravak-Stipetić
; Zavod za bolesti usta Stomatološkog fakulteta Sveučilišta u Zagrebu, Zagreb, Hrvatska
Ahmed Pirkić
; Klinički zavod za patologiju “Prof. dr. Ljudevit Jurak” Kliničke bolnice “Sestre milosrdnice” Stomatološkog fakulteta u Zagrebu, Zagreb, Hrvatska
Milutin Dobrenić
; Zavod za bolesti usta Stomatološkog fakulteta Sveučilišta u Zagrebu, Zagreb, Hrvatska
Ana Cekić-Arambašin
; Zavod za bolesti usta Stomatološkog fakulteta Sveučilišta u Zagrebu, Zagreb, Hrvatska
Sažetak
Thirty-three biopsy samples of oral lichen planus (OLP) and 18 of leukoplakia (LPL) were examined by enzyme histochemistry to determine acid phosphatase activity in epithelial cells in various clinical stages of inflammation and. hyperkeratosis in the two diseases. Significantly more activated epithelial cells, as indicated by their intense reaction to acid phosphatase (AP), were found in inflammation in OLP than in LPL (p=0.02). In severe inflammation, a decreased activity of acid phosphatase was observed in epithelial cells from both OLP and LPL samples. The AP activity reaction was most pronounced in comeal and granular epithelial cells, especially in LPL, while it was negative in basal cells of both diseases. The frequency of AP-marked cells in various clinical stages of hyperkeratosis in OLP was almost identical to that in inflammation, but opposite to the finding in LPL. These findings suggested different epithelial cell metabolism in thesame pathologic process, inflammation or hyperkeratosis, of clinically similar diseases, which may have a diagnostic and prognostic value.
Ključne riječi
oral lichen planus; leukoplakia; oral epithelium; histochemistry; acid phosphatase
Hrčak ID:
99120
URI
Datum izdavanja:
15.6.1995.
Posjeta: 1.097 *