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Differences between Keratoacanthoma and Squamous Cell Carcinoma Using TGF-á

Leo Cabrijan   ORCID icon orcid.org/0000-0002-5867-3406 ; University of Rijeka, Rijeka University Hospital Center, Department of Dermatovenereology, Rijeka, Croatia
Jasna Lipozencic ; University of Zagreb, Zagreb University Hospital Center, Department of Dermatology and Venereology, Zagreb, Croatia
Tanja Batinac ; University of Rijeka, Rijeka University Hospital Center, Department of Dermatovenereology, Rijeka, Croatia
Maja Lenkovic ; University of Rijeka, Rijeka University Hospital Center, Department of Dermatovenereology, Rijeka, Croatia
Zrinka Stanic Zgombic ; University of Rijeka, Rijeka University Hospital Center, Department of Dermatovenereology, Rijeka, Croatia

Puni tekst: engleski, pdf (178 KB) str. 147-150 preuzimanja: 219* citiraj
APA 6th Edition
Cabrijan, L., Lipozencic, J., Batinac, T., Lenkovic, M. i Stanic Zgombic, Z. (2013). Differences between Keratoacanthoma and Squamous Cell Carcinoma Using TGF-á. Collegium antropologicum, 37 (1), 147-150. Preuzeto s https://hrcak.srce.hr/99546
MLA 8th Edition
Cabrijan, Leo, et al. "Differences between Keratoacanthoma and Squamous Cell Carcinoma Using TGF-á." Collegium antropologicum, vol. 37, br. 1, 2013, str. 147-150. https://hrcak.srce.hr/99546. Citirano 24.10.2019.
Chicago 17th Edition
Cabrijan, Leo, Jasna Lipozencic, Tanja Batinac, Maja Lenkovic i Zrinka Stanic Zgombic. "Differences between Keratoacanthoma and Squamous Cell Carcinoma Using TGF-á." Collegium antropologicum 37, br. 1 (2013): 147-150. https://hrcak.srce.hr/99546
Harvard
Cabrijan, L., et al. (2013). 'Differences between Keratoacanthoma and Squamous Cell Carcinoma Using TGF-á', Collegium antropologicum, 37(1), str. 147-150. Preuzeto s: https://hrcak.srce.hr/99546 (Datum pristupa: 24.10.2019.)
Vancouver
Cabrijan L, Lipozencic J, Batinac T, Lenkovic M, Stanic Zgombic Z. Differences between Keratoacanthoma and Squamous Cell Carcinoma Using TGF-á. Collegium antropologicum [Internet]. 2013 [pristupljeno 24.10.2019.];37(1):147-150. Dostupno na: https://hrcak.srce.hr/99546
IEEE
L. Cabrijan, J. Lipozencic, T. Batinac, M. Lenkovic i Z. Stanic Zgombic, "Differences between Keratoacanthoma and Squamous Cell Carcinoma Using TGF-á", Collegium antropologicum, vol.37, br. 1, str. 147-150, 2013. [Online]. Dostupno na: https://hrcak.srce.hr/99546. [Citirano: 24.10.2019.]

Sažetak
Squamous cell carcinoma (SCC) and keratoacanthoma (KA) are skin neoplasms of epithelial origin. In contrast to clearly malignant skin neoplasm SCC, KA is an unusual cutaneous neoplasm with a tendency to regression. The distinction between these two neoplasms, on histological grounds only, is still a challenge. In order to investigate further and to assess the possible differences in transforming growth factor-alpha (TGF-a) expression between SCC and KA, 40 of skin tumor specimens, 20 cases of each SCC and KA were analyzed immunohystochemicaly. We have found a significant difference in staining patterns between KA and SCC. In KAs we have detected TGF-a staining mainly diffusely (90% of cases) and without peripheral staining of cells in 1–2 layers (60% of cases). Contrary, there was a mostly patchy staining (55% of cases) with peripheral staining of cells in 1–2 layers (100% of cases) in SCCs. Generally, differentiation between KA and SCC can be based on clinical and histological ground, but the distinction between these two skin tumors could sometimes be difficult. We have shown that these skin neoplasms could be differentiated based on staining patterns of TGF-á expression, thus this method could aid in differentiation between these two closely related entities in clinical practice.

Ključne riječi
keratoacanthoma; squamous cell carcinoma; TGF-a

Hrčak ID: 99546

URI
https://hrcak.srce.hr/99546

Posjeta: 367 *