Izvorni znanstveni članak
Genetic Analysis of Putative Familial Relationships in a Captive Chimpanzee (Pan troglodytes) Population
Renato Robledo
; University of Cagliari, Department of Biomedical Sciences, Cagliari, Italy
Joseph Lorenz
; Central Washington University, Department of Anthropology and Museum Studies, Ellensburg, WA, USA
Jeanne Beck
; Coriell Institute for Medical Research, Camden, NJ, USA
James Else
; Emory University, Yerkes National Primate Research Center, Atlanta, GA, USA
Patrick Bender
; National Institute of Mental Health, Rockville, MD, USA
Sažetak
Twelve autosomal dinucleotide repeat loci were analyzed in chimpanzees genomes by DNA amplification using primers designed for analysis of human loci. The markers span the entire length of human chromosomes 21 and 22. Nine markers were polymorphic in chimpanzee as well, with a somewhat comparable level of polymorphism and allele size range. Even in the presence of very limited information and in spite of missing samples, it was possible to reconstruct a complex pedigree and to provide molecular data that corroborate family relationships that were deduced from cage history
and behavioral data. The conclusions were further supported by mitochondrial DNA analysis. The data presented in this report show that the extremely abundant source of human markers may be exploited to validate, with molecular evidence, hypotheses on individual relationship or alleged pedigrees, based upon behavioral observations.
Ključne riječi
nonhuman primates; microsatellite; genotyping; pedigree; heterozygosity
Hrčak ID:
99584
URI
Datum izdavanja:
3.4.2013.
Posjeta: 766 *