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Osteogenesis imperfecta - pamidronate treatment in Split Clinical Hospital Centre

Ankica Kragić ; KBC Split, Odjel za nuklearnu medicinu
Goran Mijaljica ; Medicinski fakultet Sveučilišta u Splitu
Zdravka Rakuljić ; Medicinski fakultet Sveučilišta u Splitu
Neven Pavlov ; KBC Split, Klinika za dječje bolesti, Klinički odjel dječje pulmologije i kardiologije
Jasminka Pavelić ; Institut "Ruđer Bošković"
Vida Čulić   ORCID icon orcid.org/0000-0003-1352-4914 ; KBC Split, Klinika za dječje bolesti, Klinički odjel dječje pulmologije i kardiologije

Puni tekst: hrvatski, pdf (896 KB) str. 77-86 preuzimanja: 1.167* citiraj
APA 6th Edition
Kragić, A., Mijaljica, G., Rakuljić, Z., Pavlov, N., Pavelić, J. i Čulić, V. (2013). Osteogenesis imperfecta - liječenje pamidronatom u KBC-u Split. Medica Jadertina, 43 (1-2), 77-86. Preuzeto s https://hrcak.srce.hr/100571
MLA 8th Edition
Kragić, Ankica, et al. "Osteogenesis imperfecta - liječenje pamidronatom u KBC-u Split." Medica Jadertina, vol. 43, br. 1-2, 2013, str. 77-86. https://hrcak.srce.hr/100571. Citirano 15.10.2019.
Chicago 17th Edition
Kragić, Ankica, Goran Mijaljica, Zdravka Rakuljić, Neven Pavlov, Jasminka Pavelić i Vida Čulić. "Osteogenesis imperfecta - liječenje pamidronatom u KBC-u Split." Medica Jadertina 43, br. 1-2 (2013): 77-86. https://hrcak.srce.hr/100571
Harvard
Kragić, A., et al. (2013). 'Osteogenesis imperfecta - liječenje pamidronatom u KBC-u Split', Medica Jadertina, 43(1-2), str. 77-86. Preuzeto s: https://hrcak.srce.hr/100571 (Datum pristupa: 15.10.2019.)
Vancouver
Kragić A, Mijaljica G, Rakuljić Z, Pavlov N, Pavelić J, Čulić V. Osteogenesis imperfecta - liječenje pamidronatom u KBC-u Split. Medica Jadertina [Internet]. 2013 [pristupljeno 15.10.2019.];43(1-2):77-86. Dostupno na: https://hrcak.srce.hr/100571
IEEE
A. Kragić, G. Mijaljica, Z. Rakuljić, N. Pavlov, J. Pavelić i V. Čulić, "Osteogenesis imperfecta - liječenje pamidronatom u KBC-u Split", Medica Jadertina, vol.43, br. 1-2, str. 77-86, 2013. [Online]. Dostupno na: https://hrcak.srce.hr/100571. [Citirano: 15.10.2019.]

Sažetak
Osteogenesis imperfecta or brittle bone disease is a clinical, biochemical and genetical heterogeneous disorder of the connective tissue. Fragile and osteoporotic bones are its main feature. From 2002-2010 seven girls and six boys were treated at CHC Split. Based on clinical symptoms, they all had OI, eight of them had type I, two type III and the rest type V, VI and VII respectively. Eight of them were treated with intravenous application of pamidronate. This treatment increased bone density and reduced the incidence of fractures. To all of them we strongly recommended food rich in calcium and vitamins. Ten children undertook physical therapy and three had surgical procedures to correct their deformities. Pamidronate treatment abolished the occurrence of bone fractures and reduced pain in all treated children, along with the increase of bone mineral density, but without side effects caused by the drugs. In this treatment of OI, a multidisciplinary approach is
crucial. The cooperation of pediatricians – geneticists with children's surgeons, specialists in physical medicine and rehabilitation, and other specialists is very important. At CHC Split, special attention is needed for monitoring and educating children and parents on the nature of the disease and adequate rehabilitation after fracture.

Ključne riječi
osteogenesis imperfecta; osteoporosis; pamidronate; treatment; desintometry

Hrčak ID: 100571

URI
https://hrcak.srce.hr/100571

[hrvatski]

Posjeta: 1.520 *