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Endothelin-1 and its A and B receptors: Are they possibly involved in vitiligo?

Dalia Gamal Aly ; Department of Dermatology and Venereology, National Research Center, El-Bhoos St
Samar Abdallah Mohamed Salem ; Department of Dermatology and Venereology, Ain Shams University, Abasseya square
Mahmoud Fawzy Abdel-Hamid ; Department of Dermatology and Venereology, National Research Center, El-Bhoos St
Nermeen Salah Youssef ; Pathology Department, Ain Shams University, Abasseya square, Cairo, Egypt.
Marwa Abdel Moneim El Shaer ; Pathology Department, National Research Center, El-Bhoos St., Dokky, Giza, Egyp

Puni tekst: engleski, PDF (195 KB) str. 0-0 preuzimanja: 640* citiraj
APA 6th Edition
Gamal Aly, D., Abdallah Mohamed Salem, S., Fawzy Abdel-Hamid, M., Salah Youssef, N. i Abdel Moneim El Shaer, M. (2013). Endothelin-1 and its A and B receptors: Are they possibly involved in vitiligo?. Acta Dermatovenerologica Croatica, 21 (1), 0-0. Preuzeto s https://hrcak.srce.hr/101614
MLA 8th Edition
Gamal Aly, Dalia, et al. "Endothelin-1 and its A and B receptors: Are they possibly involved in vitiligo?." Acta Dermatovenerologica Croatica, vol. 21, br. 1, 2013, str. 0-0. https://hrcak.srce.hr/101614. Citirano 03.12.2021.
Chicago 17th Edition
Gamal Aly, Dalia, Samar Abdallah Mohamed Salem, Mahmoud Fawzy Abdel-Hamid, Nermeen Salah Youssef i Marwa Abdel Moneim El Shaer. "Endothelin-1 and its A and B receptors: Are they possibly involved in vitiligo?." Acta Dermatovenerologica Croatica 21, br. 1 (2013): 0-0. https://hrcak.srce.hr/101614
Harvard
Gamal Aly, D., et al. (2013). 'Endothelin-1 and its A and B receptors: Are they possibly involved in vitiligo?', Acta Dermatovenerologica Croatica, 21(1), str. 0-0. Preuzeto s: https://hrcak.srce.hr/101614 (Datum pristupa: 03.12.2021.)
Vancouver
Gamal Aly D, Abdallah Mohamed Salem S, Fawzy Abdel-Hamid M, Salah Youssef N, Abdel Moneim El Shaer M. Endothelin-1 and its A and B receptors: Are they possibly involved in vitiligo?. Acta Dermatovenerol Croat. [Internet]. 2013 [pristupljeno 03.12.2021.];21(1):0-0. Dostupno na: https://hrcak.srce.hr/101614
IEEE
D. Gamal Aly, S. Abdallah Mohamed Salem, M. Fawzy Abdel-Hamid, N. Salah Youssef i M. Abdel Moneim El Shaer, "Endothelin-1 and its A and B receptors: Are they possibly involved in vitiligo?", Acta Dermatovenerologica Croatica, vol.21, br. 1, str. 0-0, 2013. [Online]. Dostupno na: https://hrcak.srce.hr/101614. [Citirano: 03.12.2021.]

Sažetak
Background. Endothelin-1 (ET-1), expressed by keratinocytes, has paracrine effects on melanocytes. The endothelin 1-axis [ET-1, endothelin A receptor (ETAR) and endothelin B receptor (ETBR)] is thought to play a role in the depigmentation process occurring in vitiligo, with no studies on the cutaneous protein expression of this axis in the disease. Objectives. To compare the expression of ET-1 axis in lesional and perilesional normal epidermis of vitiligo patients. Methods. Ten patients with non-segmental stable vitiligo were included. Skin biopsies from all patients were studied immunohistochemically for ET-1, ETAR and ETBR expression. Results. There was no statistically significant difference between lesional vitiligo and perilesional normal epidermis regarding rates of expression of ET-1, ETAR and ETBR (P-value =0.82, 0.5 and ˃0.99 respectively). Semi quantitative analysis of ETAR revealed higher staining grades in lesional compared with perilesional normal epidermis but with a statistically significant difference (P-value =0.04). There was also no statistically significant difference between the two groups regarding the staining grades of ET-1 and ETBR (P-value>0.05 in both markers). A highly significant positive correlation was detected between ET-1 and ETAR (r =0.99, P-value <0.05) and between ET-1 and ETBR (r=0.87, P-value<0.05). Conclusion. This study shows unaltered expression of ET-1 axis in keratinocytes in lesional vitiligo and perilesional normal epidermis. Further studies on the differential expression of this axis in keratinocytes and melanocytes are therefore required.

Ključne riječi
Endothelin A receptor (ETAR); endothelin B receptor (ETBR); endothelin-1 (ET-1); melanocytes; vitiligo

Hrčak ID: 101614

URI
https://hrcak.srce.hr/101614

Posjeta: 991 *