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Bullous pemphigoid with prominent milium formation

Daisuke Tsuruta
Piotr Brzezinski
Hiroshi Koga
Chika Ohata
Minao Furumura
Takashi Hashimoto ; Department of Dermatology KURUME UNIV. SCHOOL OF MEDICINE 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan. TEL:81-942-31-7571 FAX:81-942-34-2620

Puni tekst: engleski, PDF (178 KB) str. 0-0 preuzimanja: 559* citiraj
APA 6th Edition
Tsuruta, D., Brzezinski, P., Koga, H., Ohata, C., Furumura, M. i Hashimoto, T. (2013). Bullous pemphigoid with prominent milium formation. Acta Dermatovenerologica Croatica, 21 (1), 0-0. Preuzeto s
MLA 8th Edition
Tsuruta, Daisuke, et al. "Bullous pemphigoid with prominent milium formation." Acta Dermatovenerologica Croatica, vol. 21, br. 1, 2013, str. 0-0. Citirano 22.10.2021.
Chicago 17th Edition
Tsuruta, Daisuke, Piotr Brzezinski, Hiroshi Koga, Chika Ohata, Minao Furumura i Takashi Hashimoto. "Bullous pemphigoid with prominent milium formation." Acta Dermatovenerologica Croatica 21, br. 1 (2013): 0-0.
Tsuruta, D., et al. (2013). 'Bullous pemphigoid with prominent milium formation', Acta Dermatovenerologica Croatica, 21(1), str. 0-0. Preuzeto s: (Datum pristupa: 22.10.2021.)
Tsuruta D, Brzezinski P, Koga H, Ohata C, Furumura M, Hashimoto T. Bullous pemphigoid with prominent milium formation. Acta Dermatovenerol Croat. [Internet]. 2013 [pristupljeno 22.10.2021.];21(1):0-0. Dostupno na:
D. Tsuruta, P. Brzezinski, H. Koga, C. Ohata, M. Furumura i T. Hashimoto, "Bullous pemphigoid with prominent milium formation", Acta Dermatovenerologica Croatica, vol.21, br. 1, str. 0-0, 2013. [Online]. Dostupno na: [Citirano: 22.10.2021.]

Milia are very common superficial keratinous cysts, and are clinically pearly white dome-shaped lesions with diameter of 1-2 mm.  Bullous pemphigoid (BP) is an autoimmune bullous disease, characterized clinically by tense bullae on the extremities and trunk.  The major target autoantigens of BP are BP180 and BP230.  We report a 55-year-old Polish BP patient presented prominent milium formation.  The physical examination revealed multiple tense bullae on the erythemas scattered on the extremities and trunk.  Histopathology revealed subepidermal blisters with infiltration of eosinophils in and around the blister.  Direct immunofluorescence showed IgG and C3 depositions at basement membrane zone.  Although indirect immunofluorescence of normal human skin sections was negative, indirect immunofluorescence of salt-split skin sections showed IgG reactivity with epidermal side.  Immunoblotting showed that IgG antibodies in the serum reacted with recombinant protein of BP180 NC16a domain.  ELISA of BP180, but not BP230, showed positive results.  Several months after oral prednisolone therapy, multiple large milia appeared on healed BP lesions.  Histopathology showed cysts with flaky keratinous inclusions in the mid-dermis.  We diagnosed the patient as BP with milia.  Milia are a hallmark in epidermolysis bullosa acquisita, but are rarely reported in BP.

Ključne riječi
BP180; BP230; bullous pemphigoid; epidermolysis bullosa acquisita; milia

Hrčak ID: 101617


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