APA 6th Edition Caltabiano, R., Vecchio, G.M., De Pasquale, R., Loreto, C., Leonardi, R. & Vasquez, E. (2013). Human beta-defensin 4 expression in Gianotti-Crosti Syndrome. Acta Dermatovenerologica Croatica, 21 (1), 0-0. Retrieved from https://hrcak.srce.hr/101619
MLA 8th Edition Caltabiano, Rosario, et al. "Human beta-defensin 4 expression in Gianotti-Crosti Syndrome." Acta Dermatovenerologica Croatica, vol. 21, no. 1, 2013, pp. 0-0. https://hrcak.srce.hr/101619. Accessed 3 Dec. 2021.
Chicago 17th Edition Caltabiano, Rosario, Giada Maria Vecchio, Rocco De Pasquale, Carla Loreto, Rosalia Leonardi and Enrico Vasquez. "Human beta-defensin 4 expression in Gianotti-Crosti Syndrome." Acta Dermatovenerologica Croatica 21, no. 1 (2013): 0-0. https://hrcak.srce.hr/101619
Harvard Caltabiano, R., et al. (2013). 'Human beta-defensin 4 expression in Gianotti-Crosti Syndrome', Acta Dermatovenerologica Croatica, 21(1), pp. 0-0. Available at: https://hrcak.srce.hr/101619 (Accessed 03 December 2021)
Vancouver Caltabiano R, Vecchio GM, De Pasquale R, Loreto C, Leonardi R, Vasquez E. Human beta-defensin 4 expression in Gianotti-Crosti Syndrome. Acta Dermatovenerol Croat. [Internet]. 2013 [cited 2021 December 03];21(1):0-0. Available from: https://hrcak.srce.hr/101619
IEEE R. Caltabiano, G.M. Vecchio, R. De Pasquale, C. Loreto, R. Leonardi and E. Vasquez, "Human beta-defensin 4 expression in Gianotti-Crosti Syndrome", Acta Dermatovenerologica Croatica, vol.21, no. 1, pp. 0-0, 2013. [Online]. Available: https://hrcak.srce.hr/101619. [Accessed: 03 December 2021]
The Gianotti-Crosti syndrome is a relatively common children dermatosis characterized by a monomorphus erythematous papular rash limited to the face and extensor surface of the arms and legs. Although the pathogenesis is still unclear, infections are considered as the most important factor. Human b-defensins are cationic antimicrobial peptides closely related to bacterial and viral infections of many epithelia. We herein report a case of Gianotti-Crosti syndrome in a 7 year-old Caucasian girl presented with a prominent eruption, consisting of dome-shaped lichenoid papules on her upper and lower extremities, with a spontaneous resolution. Skin biopsy revealed a dense lichenoid lymphohistiocytic infiltrate and showed strong cytoplasmic immunopositivity for human b-defensin-4 in the stratum corneum, stratum granulosum, and stratum spinosum. Considering that b-defensins have been described to be induced by infections, we investigated the expression of human b-defensin-4 by immunohistochemistry in a case of Gianotti-Crosti syndrome, in order to demonstrate that it represents a cutaneous response to skin infections.