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Acta Pharmaceutica, Vol. 63 No. 3, 2013.

Kratko priopćenje
https://doi.org/10.2478/acph-2013-0023

A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties

IVANA PERKOVIĆ ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
ZRINKA RAJIĆ DŽOLIĆ ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
BRANKA ZORC   ORCID icon orcid.org/0000-0003-4355-8816 ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (120 KB) str. 409-418 preuzimanja: 632* citiraj
APA 6th Edition
PERKOVIĆ, I., RAJIĆ DŽOLIĆ, Z. i ZORC, B. (2013). A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties. Acta Pharmaceutica, 63 (3), 409-418. https://doi.org/10.2478/acph-2013-0023
MLA 8th Edition
PERKOVIĆ, IVANA, et al. "A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties." Acta Pharmaceutica, vol. 63, br. 3, 2013, str. 409-418. https://doi.org/10.2478/acph-2013-0023. Citirano 27.05.2019.
Chicago 17th Edition
PERKOVIĆ, IVANA, ZRINKA RAJIĆ DŽOLIĆ i BRANKA ZORC. "A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties." Acta Pharmaceutica 63, br. 3 (2013): 409-418. https://doi.org/10.2478/acph-2013-0023
Harvard
PERKOVIĆ, I., RAJIĆ DŽOLIĆ, Z., i ZORC, B. (2013). 'A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties', Acta Pharmaceutica, 63(3), str. 409-418. doi: https://doi.org/10.2478/acph-2013-0023
Vancouver
PERKOVIĆ I, RAJIĆ DŽOLIĆ Z, ZORC B. A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties. Acta Pharm. [Internet]. 2013 [pristupljeno 27.05.2019.];63(3):409-418. doi: https://doi.org/10.2478/acph-2013-0023
IEEE
I. PERKOVIĆ, Z. RAJIĆ DŽOLIĆ i B. ZORC, "A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties", Acta Pharmaceutica, vol.63, br. 3, str. 409-418, 2013. [Online]. doi: https://doi.org/10.2478/acph-2013-0023

Sažetak
A convenient synthetic method for the preparation of novel NSAID twin esters 6a-i containing amino acid residue, urea and amide moieties has been developed. The synthetic pathway applied for the preparation of target compounds and key intermediates 1-benzotriazolecarboxylic acid chloride (1), NSAID benzotriazolides 2a-c and N-(1-benzotriazolecarbonyl)-amino acids 3a-d involved benzotriazole as a synthetic auxiliary. The final preparation step of esters 6a-i included the solvent-free reaction of compounds 2a-c with amino acid derivatives 5a-g, bearing two hydroxyl groups, one at each terminal, beside urea and amide functionalities.

Ključne riječi
NSAID; ester; amino acid; benzotriazole; urea; amide

Hrčak ID: 102049

URI
https://hrcak.srce.hr/102049

Posjeta: 770 *