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Acta Pharmaceutica, Vol. 63 No. 3, 2013.
Kratko priopćenje
https://doi.org/10.2478/acph-2013-0023
A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties
IVANA PERKOVIĆ
; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
ZRINKA RAJIĆ DŽOLIĆ
; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
BRANKA ZORC
orcid.org/0000-0003-4355-8816
; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
| Puni tekst: engleski, pdf (120 KB) | str. 409-418 | citiraj | |
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APA 6th Edition PERKOVIĆ, I., RAJIĆ DŽOLIĆ, Z. i ZORC, B. (2013). A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties. Acta Pharmaceutica, 63 (3), 409-418. https://doi.org/10.2478/acph-2013-0023 MLA 8th Edition PERKOVIĆ, IVANA, et al. "A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties." Acta Pharmaceutica, vol. 63, br. 3, 2013, str. 409-418. https://doi.org/10.2478/acph-2013-0023. Citirano 27.05.2019. Chicago 17th Edition PERKOVIĆ, IVANA, ZRINKA RAJIĆ DŽOLIĆ i BRANKA ZORC. "A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties." Acta Pharmaceutica 63, br. 3 (2013): 409-418. https://doi.org/10.2478/acph-2013-0023 Harvard PERKOVIĆ, I., RAJIĆ DŽOLIĆ, Z., i ZORC, B. (2013). 'A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties', Acta Pharmaceutica, 63(3), str. 409-418. doi: https://doi.org/10.2478/acph-2013-0023 Vancouver PERKOVIĆ I, RAJIĆ DŽOLIĆ Z, ZORC B. A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties. Acta Pharm. [Internet]. 2013 [pristupljeno 27.05.2019.];63(3):409-418. doi: https://doi.org/10.2478/acph-2013-0023 IEEE I. PERKOVIĆ, Z. RAJIĆ DŽOLIĆ i B. ZORC, "A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties", Acta Pharmaceutica, vol.63, br. 3, str. 409-418, 2013. [Online]. doi: https://doi.org/10.2478/acph-2013-0023 |
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Sažetak
A convenient synthetic method for the preparation of novel NSAID twin esters 6a-i containing amino acid residue, urea and amide moieties has been developed. The synthetic pathway applied for the preparation of target compounds and key intermediates 1-benzotriazolecarboxylic acid chloride (1), NSAID benzotriazolides 2a-c and N-(1-benzotriazolecarbonyl)-amino acids 3a-d involved benzotriazole as a synthetic auxiliary. The final preparation step of esters 6a-i included the solvent-free reaction of compounds 2a-c with amino acid derivatives 5a-g, bearing two hydroxyl groups, one at each terminal, beside urea and amide functionalities.
Ključne riječi
NSAID; ester; amino acid; benzotriazole; urea; amide
Hrčak ID: 102049
URI
https://hrcak.srce.hr/102049
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