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Acta Pharmaceutica, Vol. 63 No. 3, 2013.

Izvorni znanstveni članak
https://doi.org/10.2478/acph-2013-0025

Synthesis of the impurities during the manufacture of bulk drug midazolam and separation of these impurities by HPLC

BHAWANA SATI ; Department of Pharmacy, Banasthali University, Banasthali, Rajasthan, India
HEMLATA SATI ; Department of Pharmaceutical Sciences, H. N. B. Garhwal University, Srinagar Garhwal, Uttarakhand, India
SARLA SAKLANI ; Department of Pharmaceutical Sciences, H. N. B. Garhwal University, Srinagar Garhwal, Uttarakhand, India
ELLAMMA ; East Point College of Pharmacy, Bidarahalli, Virgonagar Post, Bangalore. Karnataka, India
PRAKASH CHANDRA BHATT ; Indian Medicines Pharmaceutical Corporation Ltd, Mohan, Ramnagar, India
RAVINESH MISHRA ; Institue of Pharmacy & Emerging Sciences, Baddi University of Emerging Science and Technology, Makhnumajra, Baddi, Distt. Solan, Himachal Pradesh, India

Puni tekst: engleski, pdf (318 KB) str. 385-396 preuzimanja: 2.193* citiraj
APA 6th Edition
SATI, B., SATI, H., SAKLANI, S., ELLAMMA, BHATT, P.C. i MISHRA, R. (2013). Synthesis of the impurities during the manufacture of bulk drug midazolam and separation of these impurities by HPLC. Acta Pharmaceutica, 63 (3), 385-396. https://doi.org/10.2478/acph-2013-0025
MLA 8th Edition
SATI, BHAWANA, et al. "Synthesis of the impurities during the manufacture of bulk drug midazolam and separation of these impurities by HPLC." Acta Pharmaceutica, vol. 63, br. 3, 2013, str. 385-396. https://doi.org/10.2478/acph-2013-0025. Citirano 26.05.2019.
Chicago 17th Edition
SATI, BHAWANA, HEMLATA SATI, SARLA SAKLANI, ELLAMMA, PRAKASH CHANDRA BHATT i RAVINESH MISHRA. "Synthesis of the impurities during the manufacture of bulk drug midazolam and separation of these impurities by HPLC." Acta Pharmaceutica 63, br. 3 (2013): 385-396. https://doi.org/10.2478/acph-2013-0025
Harvard
SATI, B., et al. (2013). 'Synthesis of the impurities during the manufacture of bulk drug midazolam and separation of these impurities by HPLC', Acta Pharmaceutica, 63(3), str. 385-396. doi: https://doi.org/10.2478/acph-2013-0025
Vancouver
SATI B, SATI H, SAKLANI S, ELLAMMA, BHATT PC, MISHRA R. Synthesis of the impurities during the manufacture of bulk drug midazolam and separation of these impurities by HPLC. Acta Pharm. [Internet]. 2013 [pristupljeno 26.05.2019.];63(3):385-396. doi: https://doi.org/10.2478/acph-2013-0025
IEEE
B. SATI, H. SATI, S. SAKLANI, ELLAMMA, P.C. BHATT i R. MISHRA, "Synthesis of the impurities during the manufacture of bulk drug midazolam and separation of these impurities by HPLC", Acta Pharmaceutica, vol.63, br. 3, str. 385-396, 2013. [Online]. doi: https://doi.org/10.2478/acph-2013-0025

Sažetak
During the manufacture of bulk drug midazolam various impurities arised that can be the related products or degradation products. Structures of eight impurities that can arise during the manufacture of bulk drug midazolam were proposed. In the present work, synthesis of these impurities and their characterization by different spectroscopic techniques have been done. HPLC method was developed for the separation of impurities from the bulk drug. The developed method separates midazolam from its eight impurities/degradation products within a run time of 45 min.

Ključne riječi
midazolam; impurities; degradation products; HPLC method

Hrčak ID: 102051

URI
https://hrcak.srce.hr/102051

Posjeta: 2.427 *