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Acta Pharmaceutica, Vol. 63 No. 3, 2013.

Izvorni znanstveni članak
https://doi.org/10.2478/acph-2013-0027

Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole drug for treatment of vaginal Candidiasiss

NARESH VISHAL GUPTA   ORCID icon orcid.org/0000-0002-5004-8024 ; Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore-570015, Karnataka, India
SHIRODKER NATASHA ; Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore-570015, Karnataka, India
ANIL GETYALA ; Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore-570015, Karnataka, India
RAMNATH SUDEENDRA BHAT ; Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore-570015, Karnataka, India

Puni tekst: engleski, pdf (641 KB) str. 359-372 preuzimanja: 624* citiraj
APA 6th Edition
GUPTA, N.V., NATASHA, S., GETYALA, A. i BHAT, R.S. (2013). Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole drug for treatment of vaginal Candidiasiss. Acta Pharmaceutica, 63 (3), 359-372. https://doi.org/10.2478/acph-2013-0027
MLA 8th Edition
GUPTA, NARESH VISHAL, et al. "Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole drug for treatment of vaginal Candidiasiss." Acta Pharmaceutica, vol. 63, br. 3, 2013, str. 359-372. https://doi.org/10.2478/acph-2013-0027. Citirano 23.02.2019.
Chicago 17th Edition
GUPTA, NARESH VISHAL, SHIRODKER NATASHA, ANIL GETYALA i RAMNATH SUDEENDRA BHAT. "Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole drug for treatment of vaginal Candidiasiss." Acta Pharmaceutica 63, br. 3 (2013): 359-372. https://doi.org/10.2478/acph-2013-0027
Harvard
GUPTA, N.V., et al. (2013). 'Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole drug for treatment of vaginal Candidiasiss', Acta Pharmaceutica, 63(3), str. 359-372. doi: https://doi.org/10.2478/acph-2013-0027
Vancouver
GUPTA NV, NATASHA S, GETYALA A, BHAT RS. Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole drug for treatment of vaginal Candidiasiss. Acta Pharm. [Internet]. 2013 [pristupljeno 23.02.2019.];63(3):359-372. doi: https://doi.org/10.2478/acph-2013-0027
IEEE
N.V. GUPTA, S. NATASHA, A. GETYALA i R.S. BHAT, "Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole drug for treatment of vaginal Candidiasiss", Acta Pharmaceutica, vol.63, br. 3, str. 359-372, 2013. [Online]. doi: https://doi.org/10.2478/acph-2013-0027

Sažetak
The aim of the present investigation was to prepare and evaluate novel bioadhesive vaginal tablets containing clotrimazole loaded microspheres in order to provide long-term therapeutic activity at the site of infection. Tablets were prepared by incorporating drug loaded microspheres and using bioadhesive polymers hydroxypropylmethylcellulose, sodium carboxymethylcellulose and Carbopol. Microspheres were prepared by the spray drying technique using Eudragit RS-100 and Eudragit RL-100. Microspheres were characterized by SEM, DSC, FTIR, particle size analysis and evaluated for percentage yield, drug loading, encapsulation efficiency and in vitro drug release. To achieve bioadhesion to the mucosal tissue, optimized microspheres were incorporated into bioadhesive tablets and were evaluated for in vitro drug release, in vitro and in vivo mucoadhesion. FTIR and DSC studies indicated that no chemical interaction occurred between the drug and polymers. The sphericity factor indicated that the prepared microspheres were spherical. Formulation Mt6 showed a controlled in vitro drug release and good bioadhesive strength. The in vivo images confirmed the bioadhesion and retention property of tablet up to 24 h. The results indicated that this drug delivery system can be explored for controlled intravaginal drug release.

Ključne riječi
clotrimazole; microspheres; bioadhesive vaginal tablet

Hrčak ID: 102053

URI
https://hrcak.srce.hr/102053

Posjeta: 742 *