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Croatica Chemica Acta, Vol.77 No.1-2 Svibanj 2004.

Izvorni znanstveni članak

Lipophilicity Parameters and Biological Activity in a Series of Compounds with Potential Cardiovascular Applications

Emil Pop ; Alchem Laboratories Corporation, 13305 Rachael Boulevard, Alachua, Florida 32615, USA
Daniela C. Oniciu ; Esperion Therapeutics, Inc., 3621 South State Street, 695 KMS Place, Ann Arbor, Michigan 48108, USA
Michael E. Pape ; Esperion Therapeutics, Inc., 3621 South State Street, 695 KMS Place, Ann Arbor, Michigan 48108, USA
Clay T. Cramer ; Esperion Therapeutics, Inc., 3621 South State Street, 695 KMS Place, Ann Arbor, Michigan 48108, USA
Jean-Louis H. Dasseux ; Esperion Therapeutics, Inc., 3621 South State Street, 695 KMS Place, Ann Arbor, Michigan 48108, USA

Puni tekst: engleski, pdf (225 KB) str. 301-306 preuzimanja: 2.407* citiraj
APA 6th Edition
Pop, E., Oniciu, D.C., Pape, M.E., Cramer, C.T. i Dasseux, J.H. (2004). Lipophilicity Parameters and Biological Activity in a Series of Compounds with Potential Cardiovascular Applications. Croatica Chemica Acta, 77 (1-2), 301-306. Preuzeto s https://hrcak.srce.hr/102718
MLA 8th Edition
Pop, Emil, et al. "Lipophilicity Parameters and Biological Activity in a Series of Compounds with Potential Cardiovascular Applications." Croatica Chemica Acta, vol. 77, br. 1-2, 2004, str. 301-306. https://hrcak.srce.hr/102718. Citirano 23.09.2018.
Chicago 17th Edition
Pop, Emil, Daniela C. Oniciu, Michael E. Pape, Clay T. Cramer i Jean-Louis H. Dasseux. "Lipophilicity Parameters and Biological Activity in a Series of Compounds with Potential Cardiovascular Applications." Croatica Chemica Acta 77, br. 1-2 (2004): 301-306. https://hrcak.srce.hr/102718
Harvard
Pop, E., et al. (2004). 'Lipophilicity Parameters and Biological Activity in a Series of Compounds with Potential Cardiovascular Applications', Croatica Chemica Acta, 77(1-2), str. 301-306. Preuzeto s: https://hrcak.srce.hr/102718 (Datum pristupa: 23.09.2018.)
Vancouver
Pop E, Oniciu DC, Pape ME, Cramer CT, Dasseux JH. Lipophilicity Parameters and Biological Activity in a Series of Compounds with Potential Cardiovascular Applications. Croatica Chemica Acta [Internet]. 31.05.2004. [pristupljeno 23.09.2018.];77(1-2):301-306. Dostupno na: https://hrcak.srce.hr/102718
IEEE
E. Pop, D.C. Oniciu, M.E. Pape, C.T. Cramer i J.H. Dasseux, "Lipophilicity Parameters and Biological Activity in a Series of Compounds with Potential Cardiovascular Applications", Croatica Chemica Acta, vol.77, br. 1-2, str. 301-306, svibanj 2004. [Online]. Dostupno na: https://hrcak.srce.hr/102718. [Citirano: 23.09.2018.]

Sažetak
The biological activity of some long hydrocarbon keto-diols (and their phosphate esters) and acids, has been correlated with their lipohilicity. IC50 values of the hepatocyte lipid synthesis inhibition (in vitro) were used to measure biological activity; lipohilicities were calculated by employing a 3D molecular size approach implemented in a QLogP software package. Although no quantitative correlation was observed, the results of the study might be significant for in vivo application of these compounds as potential cardiovascular agents.

Ključne riječi
cardiovascular agents; lipophilicity; log P

Hrčak ID: 102718

URI
https://hrcak.srce.hr/102718

Posjeta: 2.504 *