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The Role of Inflammation and Endothelial Dysfunction in the Pathogenesis of Diabetic Retinopathy

Martina Tomić   ORCID icon orcid.org/0000-0002-7535-3631 ; University of Zagreb, School of Medicine, »Merkur« University Hospital, »Vuk Vrhovac« University Clinic for Diabetes,
Spomenka Ljubić ; University of Zagreb, School of Medicine, »Merkur« University Hospital, »Vuk Vrhovac« University Clinic for Diabetes,
Snježana Kaštelan   ORCID icon orcid.org/0000-0002-3983-1157 ; University of Zagreb, Dubrava University Hospital, Department of Ophthalmology, Zagreb, Croatia

Puni tekst: engleski, pdf (111 KB) str. 51-57 preuzimanja: 407* citiraj
APA 6th Edition
Tomić, M., Ljubić, S. i Kaštelan, S. (2013). The Role of Inflammation and Endothelial Dysfunction in the Pathogenesis of Diabetic Retinopathy. Collegium antropologicum, 37 Supplement 1 (1), 51-57. Preuzeto s https://hrcak.srce.hr/102788
MLA 8th Edition
Tomić, Martina, et al. "The Role of Inflammation and Endothelial Dysfunction in the Pathogenesis of Diabetic Retinopathy." Collegium antropologicum, vol. 37 Supplement 1, br. 1, 2013, str. 51-57. https://hrcak.srce.hr/102788. Citirano 21.02.2020.
Chicago 17th Edition
Tomić, Martina, Spomenka Ljubić i Snježana Kaštelan. "The Role of Inflammation and Endothelial Dysfunction in the Pathogenesis of Diabetic Retinopathy." Collegium antropologicum 37 Supplement 1, br. 1 (2013): 51-57. https://hrcak.srce.hr/102788
Harvard
Tomić, M., Ljubić, S., i Kaštelan, S. (2013). 'The Role of Inflammation and Endothelial Dysfunction in the Pathogenesis of Diabetic Retinopathy', Collegium antropologicum, 37 Supplement 1(1), str. 51-57. Preuzeto s: https://hrcak.srce.hr/102788 (Datum pristupa: 21.02.2020.)
Vancouver
Tomić M, Ljubić S, Kaštelan S. The Role of Inflammation and Endothelial Dysfunction in the Pathogenesis of Diabetic Retinopathy. Collegium antropologicum [Internet]. 2013 [pristupljeno 21.02.2020.];37 Supplement 1(1):51-57. Dostupno na: https://hrcak.srce.hr/102788
IEEE
M. Tomić, S. Ljubić i S. Kaštelan, "The Role of Inflammation and Endothelial Dysfunction in the Pathogenesis of Diabetic Retinopathy", Collegium antropologicum, vol.37 Supplement 1, br. 1, str. 51-57, 2013. [Online]. Dostupno na: https://hrcak.srce.hr/102788. [Citirano: 21.02.2020.]

Sažetak
The pathogenesis of diabetic retinopathy (DR) is insufficiently understood and presumed to possibly involve inflammation and endothelial dysfunction. The aim of the study was to investigate the relationship between inflammation markers, other markers of endothelial dysfunction and anthropometric parameters and their association with DR in patients with type 2 diabetes, divided into three groups: no retinopathy (N=65), mild / moderate nonproliferative diabetic retinopathy (NPDR; N=19) and severe NPDR / proliferative diabetic retinopathy (PDR; N=23). The groups did not differ in the levels of inflammation markers, other markers of endothelial dysfunction and anthropometric parameters. C-reactive protein was correlated with fibrinogen, HbA1c, LDL-cholesterol, BMI, WC, WHR and C index. HbA1c was correlated with cholesterol, LDL-cholesterol, BMI and WC. Logistic regression analysis showed that diabetes duration and HbA1cmedian were the main predictors of retinopathy. The study demonstrated that the association between obesity, inflammation and other risk factors plays an important role in endothelial impairment involved in the pathogenesis of DR.

Ključne riječi
diabetic retinopathy; endothelial dysfunction; inflammation; obesity

Hrčak ID: 102788

URI
https://hrcak.srce.hr/102788

Posjeta: 580 *